首页|期刊导航|骨研究（英文版）|Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections

Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections

Yuehan Ni Peng Chu Dan Xing Ye Yuan Donghui Ding Ge Shen Min Yang Ronjie Wu Ling Wang Luiza Martins Nascentes Melo Sien Lin Jiamiao Wu Xiaoguang Cheng Gang Li Alpaslan Tasdogan Jessalyn M.Ubellacker Hu Zhao Shentong Fang Bo Shen Fengqi Liu Yating Yi Xiangjiao Meng Xiang Gao Luyi Xiao Weiwei Zhou Zexi Chen

骨研究（英文版）2025，Vol.13Issue(1)：104-120,17.

骨研究（英文版）2025，Vol.13Issue(1)：104-120,17.DOI:10.1038/s41413-024-00387-9

Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections

Yuehan Ni ¹Peng Chu ²Dan Xing ³Ye Yuan ³Donghui Ding ⁴Ge Shen ⁵Min Yang ¹Ronjie Wu ⁶Ling Wang ⁷Luiza Martins Nascentes Melo ⁸Sien Lin ⁶Jiamiao Wu ²Xiaoguang Cheng ⁷Gang Li ⁶Alpaslan Tasdogan ⁸Jessalyn M.Ubellacker ⁹Hu Zhao ¹⁰Shentong Fang ⁴Bo Shen ¹¹Fengqi Liu ⁴Yating Yi ¹⁰Xiangjiao Meng ¹²Xiang Gao ⁵Luyi Xiao ¹³Weiwei Zhou ²Zexi Chen¹⁰

作者信息

1. College of Life Sciences,Beijing Normal University,100875 Beijing,China||National Institute of Biological Sciences,Beijing(NIBS),102206 Beijing,China
2. National Institute of Biological Sciences,Beijing(NIBS),102206 Beijing,China||Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program,School of Life Sciences,Tsinghua University,100084 Beijing,China
3. Arthritis Clinic and Research Center,Peking University People's Hospital,Peking University,100044 Beijing,China
4. School of Biopharmacy,China Pharmaceutical University,211198 Nanjing,China
5. National Institute of Biological Sciences,Beijing(NIBS),102206 Beijing,China||Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program,Academy for Advanced Interdisciplinary Studies,Peking University,100871 Beijing,China
6. Musculoskeletal Research Laboratory,Department of Orthopaedics&Traumatology&Li Ka Shing Institute of Health Sciences,Faculty of Medicine,The Chinese University of Hong Kong,999077 Shatin,Hong Kong SAR,PR China
7. Department of Radiology,Beijing Jishuitan Hospital,Capital Medical University,National Center for Orthopaedics,100035 Beijing,China
8. Department of Dermatology,University Hospital Essen&German Cancer Consortium,Partner Site,Essen 45147,Germany
9. Department of Molecular Metabolism,Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA
10. Chinese Institute for Brain Research,Beijing(CIBR),102206 Beijing,China
11. National Institute of Biological Sciences,Beijing(NIBS),102206 Beijing,China||Tsinghua Institute of Multidisciplinary Biomedical Research,Tsinghua University,100084 Beijing,China
12. National Institute of Biological Sciences,Beijing(NIBS),102206 Beijing,China||Chinese Academy of Medical Sciences&Peking Union Medical College,100730 Beijing,China
13. National Institute of Biological Sciences,Beijing(NIBS),102206 Beijing,China
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摘要

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Yuehan Ni,Peng Chu,Dan Xing,Ye Yuan,Donghui Ding,Ge Shen,Min Yang,Ronjie Wu,Ling Wang,Luiza Martins Nascentes Melo,Sien Lin,Jiamiao Wu,Xiaoguang Cheng,Gang Li,Alpaslan Tasdogan,Jessalyn M.Ubellacker,Hu Zhao,Shentong Fang,Bo Shen,Fengqi Liu,Yating Yi,Xiangjiao Meng,Xiang Gao,Luyi Xiao,Weiwei Zhou,Zexi Chen..Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections[J].骨研究（英文版）,2025,13(1):104-120,17.

基金项目

This study was mainly supported by the National Natural Science Foundation of China(grant number 82272563 to B.S.),the National Science and Technology Major Project of the Ministry of Science and Technology of China(grant number 2023ZD0501202 to B.S.),and institutional grants allocated to the National Institute of Biological Sciences,Beijing(NIBS)from the Chinese Ministry of Science and Technology,Beijing Municipal Commission of Science and Technology,and Tsinghua University.Additionally,we acknowledge the support from China Pharmaceutical University(grant number 3150140001 to S.F.),the National Natural Science Foundation of China(grant numbers 82203653 to S.F.,82371957 to L.W.,and 82371956 to X.C.),the Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(grant number JYY2023-8 to X.C.),and the Research Grants Council of University Grants Committee Hong Kong(grant numbers 14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20).We gratefully acknowledge the generous support from these funding agencies.Furthermore,we extend our gratitude to Hongkui Zeng from the Allen Institute for providing us with the Rosa26TriGFP(Ai47)allele. （grant number 82272563 to B.S.）

骨研究（英文版）

ISSN：2095-4700

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