国际生殖健康/计划生育杂志2025，Vol.44Issue(2)：110-115,6.DOI:10.12280/gjszjk.20240416
半剂量拮抗剂对IVF/ICSI助孕结局的影响
Effect of Half-Dose Antagonist on Pregnancy Outcomes of IVF/ICSI
陆珏耘 1李欣 1季慧 1赵纯 1张军强 1凌秀凤1
作者信息
- 1. 210004 南京医科大学附属妇产医院,南京市妇幼保健院
- 折叠
摘要
Abstract
Obejective:To investigate the effect of the half-dose gonadotropin-releasing hormone antagonist(GnRH-A)on the clinical pregnancy outcomes of in vitro fertilization/intracytopiasmic sperm injection(IVF/ICSI).Methods:From January 2016 to April 2023,the clinical data of 6 211 patients who underwent IVF/ICSI in the Reproductive Medicine Center of Nanjing Maternity and Child Health Care Hospital were retrospectively analyzed.The patients were divided into the half-dose group(0.125 mg/d,1 796 cases)and the conventional-dose group(0.25 mg/d,4 415 cases),according to the daily dose of GnRH-A.Propensity scores were calculated using the daily dose of antagonist as the dependent variable to balance the two groups and control the potential confounding factors between the two groups.After matching,1 796 cases were in each group.The general condition,clinical data,embryo laboratory results,and clinical outcomes of fresh embryo transfer cycle were compared between the two groups.Results:There were no significant differences in the incidence of early luteinizing hormone(LH)peak,clinical pregnancy outcomes of fresh embryo transfer between the two groups after matching(P＞0.05).The total dose and total days of antagonist used in the half-dose group were significantly lower than those in the conventional-dose group(P＜0.001).However,the quality of D3 cleavage stage embryos in the half-dose group was lower than that in the conventional-dose group(P＜0.05),and there was no significant difference in the rate of D5 high-score blastocysts between the two groups(P＞0.05).Conclusions:In the GnRH-A regimen,the half-dose GnRH-A has the same effect on the suppression of the early LH surge as the conventional dose,and reduces the stimulation intensity and duration of GnRH-A.Further research is need to testify whether the half-dose GnRH-A regimen gets the similar pregnancy outcome of fresh embryo transfer cycles,although the half-dose GnRH-A reduces the quality of D3 cleavage stage embryos when compared with the conventional-dose GnRH-A regimen.关键词
促性腺激素释放激素拮抗剂/半剂量/体外受精/精子注射,细胞质内/妊娠结局Key words
Gonadotropin-releasing hormone antagonist/Half-dose/Fertilization in vitro/Sperm injections,intracytoplasmic/Pregnancy outcomes引用本文复制引用
陆珏耘,李欣,季慧,赵纯,张军强,凌秀凤..半剂量拮抗剂对IVF/ICSI助孕结局的影响[J].国际生殖健康/计划生育杂志,2025,44(2):110-115,6.
