国际生殖健康/计划生育杂志2025，Vol.44Issue(2)：144-149,6.DOI:10.12280/gjszjk.20240519
卵母细胞衰老机制的研究进展
Research Progress on the Mechanisms of Oocyte Aging
摘要
Abstract
Ovarian aging is the beginning of female aging,which not only relates to women's reproductive health but also serves as an important influencing factor of the low fertility rate in the nowadays society.Currently,the mechanisms of female reproductive aging have been extensively studied from multiple levels,including cellular,molecular,systemic and individual levels.This review summarizes various biological mechanisms involved in oocyte aging,such as mitochondrial function,chromosomes,oxidative stress,energy metabolism and immune factors.It also explores the progress of targeted therapies for female reproductive aging,aiming to provide important insights for preventing premature ovarian failure and even delaying reproductive aging.关键词
卵母细胞/衰老/染色体/线粒体/氧化性应激/能量代谢/免疫因素Key words
Oocytes/Aging/Chromosomes/Mitochondria/Oxidative stress/Energy metabolism/Immune factors引用本文复制引用
张江琳,袁海宁,张云洁,李恒兵,苑丽华,孙振高..卵母细胞衰老机制的研究进展[J].国际生殖健康/计划生育杂志,2025,44(2):144-149,6.基金项目
国家重点研发计划(2022YFC3500403) （2022YFC3500403）
国家自然科学基金(82274572) （82274572）
山东省重点研发计划(2023CXGC010505) （2023CXGC010505）
