摘要
Abstract
Embryonic development is the initial stage of life,which includes a series of complex biological processes from fertilized egg to embryo and then to fetus.Embryonic development is a critical period for the expression of genetic information,the formation of organ and systems,and the realization of functions,while it is the research focus of the prevention,diagnosis and treatment of related diseases.It is also directly related to the application of assisted reproductive technology.According to traditional research,the egg quality plays a decisive role in embryo development.In recent years,with the continuous development of reproductive medicine,the role of sperm factors in embryonic development has attracted wide attention.A large number of clinical studies have shown that abnormal sperm morphology,and the changes in genetic factors such as the deepening of sperm DNA damage,the increased chromosome aneuploidy rate and decreased sperm telomere length,may cause fetal dysplasia and even abortion.In addition,the non-coding RNA,proteins and metabolites of sperm are also important factors affecting embryonic development.Therefore,it is of great significance to systematically study the influence of sperm factors on embryo development,and to evaluate sperm quality and optimize sperm selection,so as to improve the optimal embryo rate and improve the pregnancy outcome.关键词
精子/胚胎发育/端粒稳态/非整倍性/流产/生殖技术,辅助Key words
Spermatozoa/Embryonic development/Telomere homeostasis/Aneuploidy/Abortion/Reproductive techniques,assisted
