临床与病理杂志2024，Vol.44Issue(11)：1496-1505,10.DOI:10.11817/j.issn.2095-6959.2024.240657
乳制品摄入与肌肉减少症风险之间的因果关系:一项两样本孟德尔随机化研究
Causal relationship between dairy intake and sarcopenia risk:A two-sample Mendelian randomization study
摘要
Abstract
Objective:Observational studies suggest that dairy intake may have a protective effect against sarcopenia,but the causal relationship between dairy consumption and the risk of sarcopenia remains unclear.This study aims to evaluate the causal relationship between dairy intake and sarcopenia using a two-sample Mendelian randomization(MR)analysis,to provide reference for clinical prevention and treatment. Methods:Summary-level data for dairy consumption(cheese,milk,yogurt,and butter)and sarcopenia-related phenotypes(appendicular lean mass,low handgrip strength,and walking pace)were obtained from the IEU open Genome-Wide Association Studies(GWAS)database.Two-sample MR analysis was performed to assess the causal relationship,with inverse variance-weighted(IVW)as the primary method and MR-Egger,weighted median(WME),simple mode(SM),and weighted mode(WM)as complementary methods. Results:IVW analysis showed causal associations between dairy intake and reduced risk of sarcopenia:cheese intake was positively associated with walking pace(OR=1.185,95%CI 1.153 to 1.219,P<0.001)and negatively associated with low handgrip strength(OR=0.757,95%CI 0.658 to 0.871,P<0.001);butter intake was positively associated with walking pace(OR=1.179,95%CI 1.007 to 1.380,P=0.041).Sensitivity analyses supported the robustness of these causal relationships.However,no causal associations were found between milk,yogurt,or butter intake and appendicular lean mass(P=0.059,P=0.768,P=0.661,respectively),or low handgrip strength(P=0.550,P=0.986,P=0.288,respectively),nor between milk/yogurt intake and walking pace(P=0.895,P=0.365,respectively). Conclusion:Cheese intake is causally associated with increased handgrip strength and faster walking pace,and butter intake is causally associated with faster walking pace.There are no causal relationships between other types of dairy products and reduced risk of sarcopenia.关键词
肌肉减少症/乳制品摄入/孟德尔随机化/敏感性分析/因果关系Key words
sarcopenia/dairy intake/Mendelian randomization/sensitivity analysis/causal relationship引用本文复制引用
王欣雨,吴迎春,严宇璐,谢松霖,邱恋,杨翔..乳制品摄入与肌肉减少症风险之间的因果关系:一项两样本孟德尔随机化研究[J].临床与病理杂志,2024,44(11):1496-1505,10.基金项目
成都医学院-成都市郫都区人民医院联合科研基金(24LHLNYX1-55).This work was supported by the Chengdu Medical College-Chengdu Pidu District People's Hospital Joint Research Fund,China(24LHLNYX1-55). （24LHLNYX1-55）
