分子影像学杂志2025，Vol.48Issue(3)：253-263,11.DOI:10.12122/j.issn.1674-4500.2025.03.01
CT影像组学联合血清参数可有效预测肝细胞癌导管动脉化疗栓塞术后的早期复发
CT radiomics combined with serum parameters can effectively predict early recurrence after transcatheter arterial chemoembolization for liver cancer
摘要
Abstract
Objective To develop a combined nomogram model based on enhanced CT imaging features and clinical indicators for predicting early recurrence(ER)in untreated intermediate-stage hepatocellular carcinoma(HCC)patients after transcatheter arterial chemoembolization(TACE),and to compare the performance of this model with radiomics and clinical models.Methods In this retrospective,two-center study,55 HCC patients who underwent enhanced CT before TACE at Affiliated Hefei First People's Hospital from February 2020 to February 2024 were randomly divided into training and validation groups using five-fold cross-validation.Clinical data,CT radiomics data,pathological data,and serum markers collected within one week before TACE were collected and evaluated for all patients.Radiomic features were selected using univariate rank sum tests and Spearman correlation analysis.Radscore was calculated based on the linear product of logistic regression model coefficients and feature values.Significant variables were identified using univariate and multivariate logistic regression,and a nomogram was constructed.The model's performance was assessed using ROC curves and decision curve analysis.Results In both the training and validation groups,the combined nomogram model had AUCs of 0.787(95%CI:0.52-1.05)and 0.847(95%CI:0.54-1.14),respectively,for predicting early recurrence after TACE.Univariate and multivariate regression analysis indicated that prothrombin time(P<0.05)was an independent serum marker associated with early recurrence after TACE.In both the training and validation groups,the AUC,accuracy,sensitivity,and specificity of the clinical model and the radiomic nomogram model alone were lower than those of the combined clinical-radiomic nomogram model.Decision curve analysis showed that the combined nomogram model had greater net benefit.Conclusion The proposed combined nomogram model has the potential to accurately predict early recurrence in HCC patients after TACE.关键词
影像组学/列线图/肝细胞癌/经导管动脉化疗栓塞/早期复发Key words
radiomics/nomogram/hepatocellular carcinoma/transcatheter arterial chemoembolization/early recurrence引用本文复制引用
孙志刚,雷学迪,孟涛,胡宇康,张宁,杨鹏辉,童钟..CT影像组学联合血清参数可有效预测肝细胞癌导管动脉化疗栓塞术后的早期复发[J].分子影像学杂志,2025,48(3):253-263,11.基金项目
安徽省高等学校科学研究项目(AHWJ2023BAa20181) （AHWJ2023BAa20181）
安徽省卫生健康科研项目(2024AH050782) （2024AH050782）
