郑州大学学报（医学版）2025，Vol.60Issue(2)：177-180,4.DOI:10.13705/j.issn.1671-6825.2024.08.059
多囊卵巢综合征患者使用卵泡期长效长方案促排卵理想FSH启动剂量的预测模型
Prediction model for ideal FSH starting dose in PCOS patients with follic-ular phase long-acting long protocol
摘要
Abstract
Aim:To construct a predictive model for the ideal starting dose of FSH in patients with polycystic ovary syndrome(PCOS)undergoing follicular phase long-acting long protocol.Methods:A retrospective analysis of clinical data from 956 PCOS patients who underwent in vitro fertilization or intracytoplasmic sperm injection at the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University between January 2022 and December 2022 was performed.Eligible patients were randomly allocated into a training set(70％,n=668)and a validation set(30％,n=288).A gener-alized linear regression model was employed to establish a predictive model for the FSH starting dose,and Bland-Altman a-nalysis was performed to test the consistency between the predicted and actual FSH starting doses.Results:The FSH start-ing dose was related to patient's age,BMI,anti-Mullerian hormone(AMH),and antral follicle count(AFC),and β(95％CI)were 1.163(1.041-1.284),3.784(3.588-3.980),-3.329(-3.629--3.028)and-1.090(-1.291--0.890),respectively.The predictive model for the starting dose of FSH was FSH(IU)=38.110+1.163 × age+3.784 × BMI-3.329 × AMH-1.090 × AFC.Bland-Altman analysis indicated that the predicted starting dose by the model was es-sentially consistent with the actual starting dose,and the difference(95％CI)were-1.79(-31.86-28.28)IU.Conclu-sion:The predictive model for the FSH starting dose is intuitive and effective,and has certain clinical practicality.关键词
卵泡期长效长方案/多囊卵巢综合征/FSH启动剂量Key words
follicular phase long-acting long protocol/polycystic ovary syndrome/FSH starting dose分类
医药卫生引用本文复制引用
孔慧娟,樊文倩,叶田,杜霖青,郭艺红..多囊卵巢综合征患者使用卵泡期长效长方案促排卵理想FSH启动剂量的预测模型[J].郑州大学学报（医学版）,2025,60(2):177-180,4.基金项目
河南省高等学校重点科研项目计划(24A320033) （24A320033）
