郑州大学学报（医学版）2025，Vol.60Issue(2)：211-215,5.DOI:10.13705/j.issn.1671-6825.2024.05.044
倍他米松磷酸钠注射液与7种注射用药物的配伍稳定性
Compatibility stability of betamethasone sodium phosphate injection with 7 injectable drugs
摘要
Abstract
Aim:To investigate the compatibility stability of betamethasone sodium phosphate injection with 7 common-ly used clinical drugs including cefazolin sodium for injection,piperacillin sodium and tazobactam sodium for injection,etc.Methods:Betamethasone sodium phosphate injection was mixed with 7 drugs including cefazolin sodium for injection,pip-eracillin sodium and tazobactam sodium for injection,cefoperazone sodium and sulbactam sodium for injection,cefuroxime sodium for injection,ceftazidime for injection,benzylpenicillin sodium for injection,lidocaine hydrochloride injection at clin-ically common doses.The compatibility solutions were observed for appearance,pH value was measured,and changes in drug content were determined by high-performance liquid chromatography under conditions of 4,25,and 40 ℃.Results:Under 4 and 25 ℃ for 24 hours and 40 ℃ for 8 hours,all 7 compatibility solutions were clear and transparent without turbidity,pre-cipitation,or flocculation.The compatibility solution of betamethasone sodium phosphate injection with cefuroxime sodium and ceftazidime for injection changed color from colorless to yellow gradually.The pH values of the 7 compatibility solutions gradually decreased or increased within 24 hours,and the changes increased with temperature.The change in betamethasone sodium phosphate content in the 7 compatibility solutions did not exceed 4％,and as the temperature decreased,the stability of the drug increased.Conclusion:The compatibility solutions of betamethasone sodium phosphate injection with the other 7 drugs remain stable within 24 hours at 4 and 25 ℃,and within 8 hours at 40 ℃.关键词
倍他米松磷酸钠注射液/外观性状/pH值/配伍稳定性Key words
betamethasone sodium phosphate injection/appearance characteristics/pH value/compatibility stability分类
医药卫生引用本文复制引用
邓博文,郑媛元,张超锋,陈迪..倍他米松磷酸钠注射液与7种注射用药物的配伍稳定性[J].郑州大学学报（医学版）,2025,60(2):211-215,5.基金项目
河南省科技攻关项目(242102311184) （242102311184）
