岭南现代临床外科2025，Vol.25Issue(1)：41-46,6.DOI:10.3969/j.issn.1009-976X.2025.01.008
骨质疏松椎体压缩性骨折PVP术后再骨折相关危险因素研究
Study on the risk factors associated with refracture after PVP for osteoporotic vertebral compres-sion fractures
摘要
Abstract
Objective This study aimed to explore the relevant risk factors for recurrent fractures after percutaneous vertebroplasty(PVP)in patients with osteoporotic vertebral compression fractures.Methods A retrospective analysis was conducted on the clinical data of patients with OVCF who under-went PVP at Shuangfeng County People's Hospital between April 2021 and June 2023.Relevant informa-tion from 409 patients was collected and categorized into a re-fracture group and a non-re-fracture group.Univariate analysis was performed on factors such as patient age,gender,time to surgery after fracture,number of initially fractured vertebrae,surgical puncture method,bone cement injection volume,presence of bone cement leakage,total protein level,globulin level,prognostic nutritional index(PNI),albumin/fibrinogen ratio(AFR),CT value,body weight,and whether regular anti-osteoporosis treat-ment was administered.Influential factors were then included in a multivariate logistic regression analysis to identify associated risk factors.Results Univariate analysis revealed significant associations between factors such as time to surgery after fracture,globulin level,albumin level,absolute lymphocyte count,fibrinogen level,PNI,AFR,CT value,surgical puncture method,and regular anti-osteoporosis treat-ment with the occurrence of re-fracture(P<0.05).Multivariate logistic regression analysis showed signifi-cant relationships between unilateral puncture as the surgical puncture method(OR=2.181,95%CI:1.249-3.809),PNI(OR=0.876,95%CI:0.821-0.934),CT value(HU)(OR=0.961,95%CI:0.948-0.974),globulin level(OR=1.078,95%CI:1.013-1.147),and lack of regular anti-osteoporosis treatment(OR=1.816,95%CI:1.029-3.206)with the occurrence of re-fracture(P<0.05).Conclusion Based on our findings,surgical puncture method,PNI,CT value,globulin level,and whether regular anti-osteoporosis treatment is administered are independent risk factors for re-fracture after PVP for OVCF.Assessing these factors may help predict the risk of re-fracture among patients and provide a reference for clinical intervention and treatment strategy formulation.关键词
骨质疏松/椎体压缩性骨折/PVP术/再骨折/危险因素Key words
osteoporosis/vertebral compression fractures/percutaneous vertebroplasty/recurrent fractures/risk factors分类
临床医学引用本文复制引用
刘思定,王云..骨质疏松椎体压缩性骨折PVP术后再骨折相关危险因素研究[J].岭南现代临床外科,2025,25(1):41-46,6.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20220589) （LHGJ20220589）
