检验医学与临床2025，Vol.22Issue(7)：865-868,873,5.DOI:10.3969/j.issn.1672-9455.2025.07.001
基于NF-κB信号通路探讨奥美拉唑联合西咪替丁对慢性胃炎的临床疗效
Exploring the clinical efficacy of omeprazole combined with cimetidine in chronic gastritis based on NF-κB signaling pathway
摘要
Abstract
Objective To explore the clinical efficacy of omeprazole combined with cimetidine on chronic gastritis based on nuclear transcription factor-κB(NF-κB)signaling pathway.Methods From February 2022 to March 2023,120 patients with chronic gastritis admitted to Beijing Friendship Hospital,Capital Medical U-niversity were gathered and randomly divided into the control group and the combined group,with 60 cases in each group.The control group was treated with oral cimetidine,and the combined group was treated with omeprazole on the basis of control.The efficacy of the two groups was compared,and the changes of NF-κB P50,NF-κB P65,gastrointestinal hormones[gastrin 17(GAS-17)and gastric motility(MTL)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)]and gastric mo-tility indexes(gastric electrical rhythm and gastric motility rhythms).Results The total effective rate of the combined group was significantly higher than that of the control group,the difference was statistically signifi-cant(χ2=6.508,P=0.011).The levels of NF-κB P50 and NF-κB P65,as well as the levels of serum TNF-α,IL-6 and CRP after treatment were lower than those before treatment in both groups,the levels of serum GAS-17,MTL,gastric electrical rhythm and gastric motility rhythm after treatment in bothe groups were higher than those before treatment,the differences were significant(P<0.05).After treatment,the levels of NF-κB P50,NF-κB P65,TNF-α,IL-6 and CRP in the combination group were lower than those in the control group,while the levels of serum GAS and MTL,as well as gastric electrical and motility rhythm were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion Omeprazole combined with cimetidine is effective in the treatment of chronic gastritis,which can improve the secretion function of gastrointestinal hormones,improve gastric motility,and reduce the inflammatory response,and its mechanism may be related to the inhi-bition of NF-κB signaling pathway.关键词
核转录因子-κB/信号通路/奥美拉唑/西咪替丁/慢性胃炎/疗效Key words
nuclear transcription factor-κB/signaling pathway/omeprazole/cimetidine/chronic gastritis分类
临床医学引用本文复制引用
李嘉琦,宁炜,褚芮,孙伟..基于NF-κB信号通路探讨奥美拉唑联合西咪替丁对慢性胃炎的临床疗效[J].检验医学与临床,2025,22(7):865-868,873,5.基金项目
北京市实验室生物安全管理质量提高项目(京生安2024-10). （京生安2024-10）
