检验医学与临床2025，Vol.22Issue(7)：874-879,6.DOI:10.3969/j.issn.1672-9455.2025.07.003
血清尿素氮、25-(OH)D3、IGF-1水平与学龄前营养不良儿童STRONGkids评分的相关性及对临床结局的预测价值
Correlation between serum urea nitrogen,25-(OH)D3,IGF-1 and STRONGkids score in preschool children with malnutrition and their predictive value for clinical outcomes
摘要
Abstract
Objective To investigate the correlation of serum urea nitrogen,25-hydroxyvitamin D3[25-(OH)D3],insulin growth factor 1(IGF-1)and screening tool for risk of nutrition in growth kids(STRONGkids)scores in preschool children with malnutrition,and to analyze the predictive value of clinical outcomes.Methods A total of 116 preschool malnourished children admitted to the hospital from January to December 2023 were selected as the observation group,and 116 healthy preschool children who underwent physical examination during the same period were selected as the control group by ratio of 1∶1.The levels of serum urea nitrogen,25-(OH)D3,IGF-1 and STRONGkids score were compared between the observation group before intervention and the control group.The correlation between serum urea nitrogen,25-(OH)D3,IGF-1 and STRONGkids score in the observation group before intervention was analyzed.The levels of serum urea nitrogen,25-(OH)D3 and IGF-1 before and after intervention for 2 months were compared in children with different clinical outcomes.The predictive value of serum urea nitrogen,25-(OH)D3 and IGF-1 on the poor clinical outcomes of preschool children with malnutrition before and after intervention for 2 months was analyzed,as well as their impact on the risk of poor clinical outcomes.Results The STRONGkids score of the observation group before intervention was higher than that of the control group,and the levels of serum urea nitrogen,25-(OH)D3 and IGF-1 were lower than those of the control group,with statistically significant differences(P<0.05).Before intervention,serum urea nitrogen,25-(OH)D3,IGF-1 and STRONGkids scores correlated negatively(r=—0.744,—0.676,—0.737,P<0.05).Before intervention and after 2 months of in-tervention,the levels of serum urea nitrogen,25-(OH)D3 and IGF-1 of the poor outcome preschool children were lower than those in the good outcome preschool children,and the differences were statistically significant(P<0.05).The area under the area(AUC)of the combined prediction of serum urea nitrogen,25-(OH)D3,and IGF-1 before and after intervention for 2 months was 0.883 and 0.908 respectively,which was signifi-cantly larger than that of each indicator alone(P<0.05).Serum urea nitrogen,25-(OH)D3 and IGF-1 were classified into high expression(>cut-off value)and low expression(≤cut-off value)based on the cut-off val-ue of ROC curve analysis before and 2 months after intervention.Relative risk(RR)analysis showed that high expression of serum urea nitrogen,25-(OH)D3 and IGF-1 before and 2 months after intervention could reduce the risk of adverse clinical outcomes in preschool children with malnutrition(pre intervention:RR=0.178,0.257,0.244,P<0.001;after 2 months of intervention:RR=0.183,0.228,0.222,P<0.001).Conclusion The levels of serum urea nitrogen,25-(OH)D3 and IGF-1 in preschool malnourished children relate closely to the STRONGkids score and clinical outcomes,and the combined levels of serum urea nitrogen,25-(OH)D3 and IGF-1 can be used to assist in predicting the clinical outcomes of children.关键词
尿素氮/25-羟维生素D3/胰岛素生长因子1/学龄前/营养不良/营养状况和生长风险筛查工具/临床结局Key words
urea nitrogen/25-hydroxyvitamin D3/insulin growth factor 1/preschool/malnutri-tion/screening tool for risk of nutrition in growth kids/clinical outcome分类
临床医学引用本文复制引用
郭江,李佳育,李薇,余涛..血清尿素氮、25-(OH)D3、IGF-1水平与学龄前营养不良儿童STRONGkids评分的相关性及对临床结局的预测价值[J].检验医学与临床,2025,22(7):874-879,6.基金项目
2021年四川省医学(青年创新)科研课题项目(S211128). （青年创新）
