检验医学与临床2025，Vol.22Issue(7)：889-893,5.DOI:10.3969/j.issn.1672-9455.2025.07.006
脑梗死患者Hcy、BDNF、APO-A/APO-B比值变化及其与神经功能缺损程度的关系
Expression levels of Hcy,BDNF and APO-A/APO-B ratio,and their relationship with the severity of neurological impairment in patients with cerebral infarction
摘要
Abstract
Objective To analyze the changes in serum homocysteine(Hcy),brain-derived neurotrophic factor(BDNF),apolipoprotein(APO)-A/APO-B ratio and their relationship with the degree of neurological dysfunction in patients with cerebral infarction.Methods A total of 104 patients diagnosed with cerebral in-farction in the hospital from March 2020 to March 2022 were selected as the case group,and 52 patients who underwent physical examinations in the hospital during the same period were selected as the control group.According to the National Institutes of Health Stroke Scale(NIHSS)score,patients in the case group were di-vided into mild neurological deficit(mild group,score 1-14),moderate neurological deficit(moderate group,score 5-15),and severe neurological deficit(severe group,score 16-42).The levels of serum Hcy,BDNF,APO-A and APO-B in all patients were detected,and calculate the APO-A/APO-B ratio.The levels of serum Hcy,BDNF and APO-A/APO-B ratio between the case group and the control group,in stroke patients with different degrees of neurological deficits were compared.Pearson correlation analysis was used to investigate the correlation among serum Hcy,BDNF and APO-A/APO-B ratio in stroke patients.Spearman correlation a-nalysis was used to investigate the correlation between serum Hcy,BDNF,APO-A/APO-B ratio and neuro-logical deficits in patients with cerebral infarction.The evaluation value of serum Hcy,BDNF levels and APO-A/APO-B ratio for moderate to severe neurological deficits in patients with cerebral infarction was analyzed u-sing receiver operating characteristic(ROC)curve analysis.Results The results showed that the serum Hcy level in the case group was higher than that in the control group,while the serum BDNF level and APO-A/APO-B ratio were lower than those in the control group,and the differences were statistically significant(P<0.05).Comparison of serum Hcy levels:mild group<moderate group<severe group,pairwise comparison showed statistically significant differences(P<0.05).Comparison of BDNF levels and APO-A/APO-B ratio in the case group:mild group>moderate group>severe group,pairwise comparisons showed statistically sig-nificant differences(P<0.05).The serum Hcy level correlated negatively with the serum BDNF level and APO-A/APO-B ratio(r=-5.293,-6.257,P<0.05),while the serum BDNF level correlated positively with the APO-A/APO-B ratio(r=5.384,P<0.05).The serum Hcy level correlated positively with the de-gree of neurological deficit(r=5.179,P<0.05),while the serum BDNF level and APO-A/APO-B ratio cor-related negatively with the degree of neurological deficit(r=-6.042,-6.133,P<0.05).The ROC curve a-nalysis results showed that the AUC of serum Hcy,BDNF levels,and APO-A/APO-B ratio for evaluating moderate to severe neurological deficits were 0.815,0.781and 0.770 respectively.Conclusion Patients with cerebral infarction have elevated serum Hcy levels,decreased serum BDNF levels and APO-A/APO-B ratio.Serum Hcy level correlates positively with the degree of neurological dysfunction,while serum BDNF level and APO-A/APO-B ratio correlate negatively with the degree of neurological dysfunction.关键词
脑梗死/同型半胱氨酸/脑源性神经营养因子/载脂蛋白/神经功能Key words
cerebral infarction/homocysteine/brain-derived neurotrophic factor/apolipoprotein/neurological function分类
临床医学引用本文复制引用
郭晓玉,谷伟,王彦伟,贾海莉,董霞..脑梗死患者Hcy、BDNF、APO-A/APO-B比值变化及其与神经功能缺损程度的关系[J].检验医学与临床,2025,22(7):889-893,5.基金项目
河北省卫生健康委员会课题(20231460). （20231460）
