检验医学与临床2025，Vol.22Issue(7)：894-898,904,6.DOI:10.3969/j.issn.1672-9455.2025.07.007
维持性血液透析患者血清MGP、MCP-1水平及其对患者并发主要心血管不良事件的预测价值
Expression levels of serum MGP and MCP-1 in maintenance hemodialysis patients and their predictive value for major cardiovascular adverse events in patients
摘要
Abstract
Objective To explore the levels of serum matrix Gla protein(MGP)and monocyte chemoat-tractant protein-1(MCP-1)in maintenance hemodialysis patients,and their predictive value for major cardio-vascular adverse events during maintenance hemodialysis.Methods A total of 182 maintenance hemodialysis patients admitted from January 2022 to November 2023 were selected as the observation group.Based on whether the patients had major cardiovascular adverse events during the 6-month follow-up period,the obser-vation group was divided into non concurrent group and concurrent group.Other 182 healthy volunteers who underwent physical examinations during the same period were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect the serum levels of MGP and MCP-1 in all study subjects.Multivariate Logistic regression analysis was used to investigate the influencing factors of major cardiovascular adverse events in maintenance hemodialysis patients.The predictive efficacy of serum MGP and MCP-1 for major cardiovascular adverse events during maintenance hemodialysis was analyzed using receiver operating characteristic(ROC)curve.Results Compared with the control group,the observation group showed a de-crease in serum MGP level and an increase in MCP-1 level,with statistically significant differences(P<0.05).According to the incidence of major cardiovascular adverse events during the 6-month follow-up period,the observation group was divided into a concurrent group of 63 cases and a non concurrent group of 119 ca-ses.Compared with the non concurrent group,the concurrent group showed a decrease in serum MGP level and an increase in MCP-1 level,with statistically significant differences(P<0.05).Compared with the non concurrent group,the dialysis age in the concurrent group was longer,the blood calcium,blood phosphorus and total parathyroid hormone levels in the concurrent group were lower(P<0.05).The results of multivariate Logistic regression analysis showed that dialysis age,blood calcium,blood phosphorus,whole segment para-thyroid hormone,MCP-1 and MGP were the main influencing factors of cardiovascular adverse events in main-tenance hemodialysis(P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)of the combined detection of serum MGP and MCP-1 predicted major cardiovascular adverse events in maintenance hemodialysis patients was 0.863,which was significantly larger than the AUC predicted by MGP and MCP-1 alone(Z=2.164,P=0.030;Z=2.280,P=0.023).Conclusion The serum MGP expression level decreases and MCP-1 expression level increases in maintenance hemodialysis patients,which relate to the oc-currence of major cardiovascular adverse events.The combined prediction of the two indicators has a higher predictive power for the occurrence of major cardiovascular adverse events in maintenance hemodialysis patients.关键词
维持性血液透析/基质Gla蛋白/单核细胞趋化蛋白-1/主要心血管不良事件/预测Key words
maintenance hemodialysis/matrix Gla protein/monocyte chemoattractant protein-1/major cardiovascular adverse event/prediction分类
医药卫生引用本文复制引用
王丽娟,王莉丽,侯儆,李旭霞..维持性血液透析患者血清MGP、MCP-1水平及其对患者并发主要心血管不良事件的预测价值[J].检验医学与临床,2025,22(7):894-898,904,6.基金项目
河北省 2022年度医学科学研究课题计划(20221900). （20221900）
