检验医学与临床2025，Vol.22Issue(7)：905-909,5.DOI:10.3969/j.issn.1672-9455.2025.07.009
OSAHS患者血清IGF-1、HIF-1α水平与病情及并发缺血性脑卒中的关系
Serum IGF-1 and HIF-1α levels in patients with obstructive sleep apnea-hypopnea syndrome and the relationship with the severity disease and complicated ischemic stroke
摘要
Abstract
Objective To investigate the relationship between the serum insulin-like growth factor-1(IGF-1)and hypoxia inducible factor-1α(HIF-1α)levels,the severity of obstructive sleep apnea-hypopnea syndrome(OSAHS)and the occurrence of ischemic stroke in patients.Methods A total of 110 patients with obstructive sleep apnea-syndrome(OSAHS)who received treatment at Tongzhou District People's Hospital from January 2023 to January 2024 were selected as the research subjects.OSAHS patients were divided into mild group and moderate to severe group based on the apnea hypopnea index(AHI),and divided into simple OSAHS group(69 cases)and complicated ischemic stroke group(41 cases)based on whether ischemic stroke occurred.The serum levels of IGF-1 and HIF-1 α were compared among OSAHS patients with different degrees of illness.Pearson correlation analysis was used to investigate the correlation between serum IGF-1 and HIF-1 α levels and AHI.Multivariate Logistic regression analysis was used to identify the infect factors complicating ische-mic stroke in OSAHS patients.Receiver operating characteristic(ROC)curve was used to analyze the predic-tive value of serum IGF-1 and HIF-1α for complicating ischemic stroke in OSAHS patients.Results Com-pared with the mild group,the serum IGF-1 level in the moderate to severe group reduced significantly,while the levels of HIF-1 α and AHI increased significantly,and the differences were statistically significant(P<0.05).The serum IGF-1 level in OSAHS patients correlated negatively with AHI(r=—0.389,P<0.05),while the serum HIF-1 α level in OSAHS patients correlated positively with AHI(r=0.431,P<0.05).Compared with the simple OSAHS group,the serum IGF-1 level in the complicated ischemic stroke group reduced signif-icantly,while the HIF-1α level increased significantly,and the differences were statistically significant(P<0.05).The results of multivariate Logistic regression analysis showed that elevated AHI and HIF-1α levels were risk factors for complicating ischemic stroke in OSAHS patients(P<0.05),while elevated MinSpO2 and IGF-1 levels were protective factors for complicating ischemic stroke in OSAHS patients(P<0.05).The combined prediction of serum IGF-1 and HIF-1 α for the area under the curve(AUC)of ischemic stroke in OSAHS patients was 0.900,which was significantly higher than the AUC predicted by the two indicators a-lone(P<0.05).Conclusion Decreased serum IGF-1 and elevated HIF-1α aggravated the condition of OS-AHS patients,and increased the risk of ischemic stroke in OSAHS patients.The value of combination of ser-um IGF-1 and HIF-1α for predicting complicated ischemic stroke in OSAHS is significant.关键词
阻塞性睡眠呼吸暂停低通气综合征/缺血性脑卒中/胰岛素样生长因子-1/缺氧诱导因子-1α/呼吸暂停低通气指数Key words
obstructive sleep apnea-hypopnea syndrome/ischemic stroke/insulin-like growth factor-1/hypoxia-inducible factor-1α/apnea hypopnea index分类
医药卫生引用本文复制引用
黄敏,葛珊珊,王祎,倪盼盼,成炜..OSAHS患者血清IGF-1、HIF-1α水平与病情及并发缺血性脑卒中的关系[J].检验医学与临床,2025,22(7):905-909,5.基金项目
江苏省南通市卫生健康委员会科研项目(QN2023070). （QN2023070）
