检验医学与临床2025，Vol.22Issue(7)：964-968,5.DOI:10.3969/j.issn.1672-9455.2025.07.020
CCTA联合血清miR-186-5p、miR-150-5p在冠心病中的诊断价值
Diagnosis value of CCTA combined with serum miR-186-5p and miR-150-5p levels in coronary heart disease
摘要
Abstract
Objective To explore the diagnosis value of coronary artery angiography(CCTA)combined with serum miR-186-5p and miR-150-5p levels in coronary heart disease(CHD).Methods A total of 135 CHD patients accepted in the Second Affiliated Hospital of Hebei North University from December 2021 to December 2023 were collected as the CHD group.A total of 135 healthy volunteers who underwent normal physical examinations were collected in the control group.Kappa consistency was applied to analyze the con-sistency between CCTA detection and CHD with the Coronary Angiography(CAG,"gold standard").The re-ceiver operating characteristic(ROC)curve was used to analyze the cut-off values of serum miR-186-5p and miR-150-5p in the diagnosis of CHD.The diagnostic value of CCTA combined with serum miR-186-5p and miR-150-5p levels in CHD was analyzed by four-grid table.The factors affecting CHD were analyzed using multivariate Logistic regression analysis.Results The results of CCTA diagnosis for CHD showed that 124 cases were positive,with a detection rate of 45.93%(124/270),146 cases were negative,with a detection rate of 54.07%(146/270).Among 135 CHD patients,30 cases were misdiagnosed by CCTA,with a misdiagnosis rate of 22.22%(30/135),among 135 healthy volunteers,19 cases were misdiagnosed using CCTA,with a mis-diagnosis rate of 14.07%(19/135),which was consistent with the"gold standard"diagnosis(Kappa=0.637,P<0.05).Compared with the control group,the expression level of miR-186-5p in the CHD group increased,while the expression level of miR-150-5p decreased,the differences were significant(P<0.05).The cut-off values of miR-186-5p and miR-150-5p in the diagnosis of CHD were 1.190 and 0.759 respectively.The accura-cy of CCTA combined with serum miR-186-5p and miR-150-5p in the diagnosis of CHD was 82.96%,and the sensitivity was 80.74%,which were higher than those of CCTA,miR-186-5p and miR-150-5p alone(P<0.05).Multivariate Logistic analysis showed that miR-186-5p and miR-150-5p were the factors influencing CHD(P<0.05).Conclusion CHD patients,serum miR-186-5p level increases while miR-150-5p decreases.CCTA imaging combined with serum miR-186-5p and miR-150-5p levels is the most effective in diagnosing CHD.关键词
心脏冠状动脉血管成像/miR-186-5p/miR-150-5p/冠心病/诊断Key words
coronary artery angiography/miR-186-5p/miR-150-5p/coronary heart disease/diag-nosis分类
临床医学引用本文复制引用
刘扬,宋彦丽,姚旭成,孙红红,周建昌,李金巍,程光辉..CCTA联合血清miR-186-5p、miR-150-5p在冠心病中的诊断价值[J].检验医学与临床,2025,22(7):964-968,5.基金项目
河北省张家口市重点研发计划项目(2021120D). （2021120D）
