检验医学与临床2025，Vol.22Issue(7)：969-973,977,6.DOI:10.3969/j.issn.1672-9455.2025.07.021
炎症因子、心功能指标与重症脓毒症患者心功能损伤的相关性分析
Relationship between cardiac function damage in patients with severe sepsis and inflammatory factors,cardiac function indicators
摘要
Abstract
Objective To explore the expression levels of inflammatory factors and cardiac function indica-tors in the serum of patients with severe sepsis and their relationship with cardiac function damage.Methods A total of 80 patients with severe sepsis who were treated in Dongguan Binhai Bay Central Hospital from January 2021 to November 2022 were selected according to left ventricular ejection fraction(LVEF),they were grouped into cardiac function injury group and non-cardiac function injury group.The levels of N-terminal pro-brain natriuretic peptide precursor(NT-proBNP),troponin I(cTNI),creatine kinase isoenzyme(CKMB)and inflammatory factors-C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6),Sequential Organ Failure Assessment(SOFA)score and Acute Physiologi-cal And Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score were compared between the two groups.The cor-relation between cardiac function indexes,inflammatory factors,SOFA,APACHEⅡ scores and myocardial in-jury indexes in patients with severe sepsis was analyzed by Pearson correlation.Results A total of 28 cases in the heart function injury group and 52 cases in the non heart function injury group.LVEF and ratio of mitral E peak to A peak(E/A)in the cardiac function injury group were obviously lower than those in the non-cardiac function injury group,the left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diame-ter(LVESD),left ventricular short axis shortening rate(FS),ventricular septal end-diastolic thickness(IVS),SOFA,APACHEⅡ scores in the cardiac function injury group were obviously higher than those in the non-cardiac function injury group,the differences were significant(P<0.05).CKMB,cTnI and NT-proBNP in cardiac function injury group were obviously higher than those in non-cardiac function injury group,the ex-pression levels of CRP,PCT,TNF-α and IL-6 in the cardiac function injury group were obviously higher than those in non-cardiac function injury group(P<0.05).Correlation analysis showed that LVEF correlated neg-atively with CKMB,cTnI,NT-proBNP,CRP,PCT,TNF-α,IL-6,SOFA score,APACHEⅡ score(P<0.05).E/A correlated negatively with cTnI,NT-proBNP,PCT,TNF-α,SOFA score and APACHEⅡ score(P<0.05).FS correlated positively with CKMB,cTnI,PCT,TNF-α,IL-6,SOFA score and APACHEⅡ score(P<0.05).LVEDD,LVESD,IVS correlated obviously positively with CKMB,cTnI,NT-proBNP,CRP,PCT,TNF-α,IL-6,SOFA score and APACHEⅡ score(P<0.05).Conclusion The expression of inflammatory factors and myocardial injury indicators in patients with severe sepsis and cardiac function injury increase sig-nificantly,and correlate significantly with cardiac function injury indicators of patients,which provides refer-ence for clinical evaluation of cardiac function in patients with severe sepsis.关键词
炎症因子/心功能指标/重症脓毒症/心功能损伤/相关性分析Key words
inflammatory factor/cardiac function indicator/severe sepsis/cardiac function damage/correlation alaysis分类
临床医学引用本文复制引用
伍伟光,颜建辉,何敏锋,陈小武,林子靖..炎症因子、心功能指标与重症脓毒症患者心功能损伤的相关性分析[J].检验医学与临床,2025,22(7):969-973,977,6.基金项目
2023年东莞市社会发展科技项目(20231800904482). （20231800904482）
