检验医学与临床2025，Vol.22Issue(7)：974-977,4.DOI:10.3969/j.issn.1672-9455.2025.07.022
miR-224、ATG5在早发型子痫前期中的预测价值
Study on the predictive value of miR-224,ATG5 for early-onset preeclampsia
摘要
Abstract
Objective To explore the predictive value of miR-224 and autophagy related gene-5(ATG5)for early-onset preeclampsia.Methods A total of 35 cases of simple pregnancy induced hypertension treated in the Department of Obstetrics in Hebei Petro China Central Hospital from December 2021 to October 2022 were selected as group A,35 cases of early-onset preeclampsia were selected as group B,and 35 normal preg-nancy volunteers were selected as the control group.Collect prenatal serum samples from three groups of par-turients,and use reverse transcription fluorescence quantitative polymerase chain reaction to detect the expres-sion of miR-224 and ATG5.The differences in serum miR-224 and ATG5 expression among different groups were compared,multivariate Logistic regression analysis was used to investigate the influencing factors of ear-ly-onset preeclampsia.Pearson correlation analysis was used to investigate the correlation between miR-224 level and ATG5 ilevel n patients with early-onset preeclampsia.The value of receiver operating characteristic(ROC)curve was used to analyze miR-224 and ATG5 in predicting the onset of early-onset preeclampsia.Re-sults Compared with the control group,the levels of serum miR-224 and ATG5 increased in group A and group B,the differences were statistically significant(P<0.05).Compared with group A,the levels of serum miR-224 and ATG5 in group B increased significantly,and the differences were statistically significant(P<0.05).Elevated levels of miR-224 and ATG5 were risk factors for early-onset preeclampsia(P<0.05).Pear-son correlation analysis found a positive correlation between miR-224 level and ATG5 level in patients with early-onset preeclampsia(r=0.457,P<0.05).The area under the ROC curve(AUC)of serum miR-224 and ATG5 for predicting the early-onset preeclampsia were 0.823 and 0.754 respectively.The AUC of the com-bined prediction of miR-224 and ATG5 for early-onset preeclampsia was 0.922,which was significantly greater than the AUC predicted by each individual(Z=2.122,P<0.05;Z=2.716,P<0.05).Conclusion Serum miR-224 and ATG5 levels have certain predictive value for the early-onset preeclampsia.关键词
miR-224/自噬相关基因-5/早发型子痫前期/聚合酶链反应/妊娠期高血压Key words
miR-224/autophagy related gene-5/early-onset preeclampsia/polymerase chain reac-tion/pregnancy induced hypertension分类
临床医学引用本文复制引用
吴亚男,郝媛媛,安泓润..miR-224、ATG5在早发型子痫前期中的预测价值[J].检验医学与临床,2025,22(7):974-977,4.基金项目
河北省廊坊市科技支撑计划项目(2022013125). （2022013125）
