检验医学与临床2025，Vol.22Issue(7)：983-986,992,5.DOI:10.3969/j.issn.1672-9455.2025.07.024
血清LRG1与ACR在高血压肾损伤中的水平及意义
The levels and significance of serum LRG1 and ACR in hypertensive kidney injury
摘要
Abstract
Objective To explore the levels and significance of serum leucine rich α2-glycoprotein 1(LRG1)and urinary microalbumin(UmAlb)/urinary creatinine(UCr)ratio(ACR)in hypertensive kidney injury.Methods A total of 161 hypertensive patients admitted to Shanghai Yangpu District Kongjiang Hospi-tal from March 2023 to November 2023 were selected for this study,of which 96 hypertensive nephropathy pa-tients were treated as the hypertensive kidney injury group,65 simple hypertension patients were treated as the simple hypertension group,and 62 volunteers who had their health checkups in this hospital during the same period were selected as the control group.Serum LRG1 level was measured by enzyme-linked immu-nosorbent assay.UmAlb,UCr,blood urea nitrogen(BUN),β2-Microglobulin(β2-MG)and uric acid(UA)levels were detected by fully automated biochemistry analyzer.The correlation between LRG1,ACR levels and BUN,β2-MG,UA levels was analyzed by Pearson correlation.Multivariate Logistic regression analysis was used to investigate the influencing factors of hypertensive kidney injury.Receiver operating characteristic(ROC)curve was used to analyze the early diagnostic value of serum LRG1 and ACR levels for hypertensive kidney injury.Results The serum levels of LRG1,ACR,BUN,β2-MG and UA in the hypertensive kidney in-jury group were higher than those in the simple hypertension group and the control group.The serum levels of LRG1,ACR,BUN,β2-MG and UA in the hypertensive kidney injury group were higher than those in the sim-ple hypertension group,the differences were statistically significant(P<0.05).The serum levels of LRG1 and ACR in patients with stage 1,stage 2 and stage 3 hypertensive kidney injury increased sequentially,and the differences were statistically significant(P<0.05)when compared pairwise.Multivariate Logistic regres-sion analysis showed that serum LRG1,ACR,BUN,β2-MG and UA were the influencing factors of hyperten-sive kidney injury(P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)of serum LRG1,ACR and their combined diagnosis of hypertensive kidney injury were 0.833,0.835 and 0.901 respectively.The AUC of their combined diagnosis was significantly higher than that of serum LRG1,ACR a-lone(Z=2.415,Z=2.085,P<0.05).Conclusion Serum LRG1 and ACR are risk factors for hypertensive renal injury,and they have ideal value for diagnosing hypertensive renal injury,and the efficacy of combined di-agnosis of the two indicators is better.关键词
富亮氨酸α2-糖蛋白1/尿微量清蛋白/尿肌酐比值/高血压肾损伤/早期诊断Key words
leucine rich α2-glycoprotein 1/urinary microalbumin/urinary creatinine ratio/hypertensive kidney injury/early diagnosis分类
临床医学引用本文复制引用
蔡凤,王琳琳,张雨帆..血清LRG1与ACR在高血压肾损伤中的水平及意义[J].检验医学与临床,2025,22(7):983-986,992,5.基金项目
2023年度上海市杨浦区控江医院中青年骨干培养项目(杨控医党内[2022]7号). （杨控医党内[2022]7号）
