经济动物学报2025，Vol.29Issue(2)：139-145,7.DOI:10.13326/j.jea.2025.2072
我国部分地区猫白血病病毒的流行状况及env基因的遗传进化分析
Epidemic Tendency of Feline Leukemia Virus and Genetic Evolution Analysis of env Gene in Some Regions of China
摘要
Abstract
In order to clarify the prevalence of feline leukemia virus(FeLV)and genetic evolution of the env gene in some regions of China,clinical samples of cats collected in five different cities in Shandong Province,Hebei Province,and Beijing City during 2023 were detected and evolution and variation analysis of env gene were conducted.Results indicated that the positive rate of FeLV was 50.29%,and some differences were in different regions.Phylogenetic analysis of 61 env genes showed that circulating FeLVs could be divided into two parts(FA and FD)currently,and FeLV-A was the main one.There were 23 regular mutation sites between major branches in phylogenetic tree,which could serve as genetic markers for the two parts.The amino acid sequences of FA were relatively conserved,while 60 amino acid insertion displayed at the C-terminus of FD,which formed new branches in their corresponding branches of phylogenetic tree.The result indicated that the virus derived new genetic characteristics during the evolution process.Overall,the results in this study could provide reliable basis for the implement of measures and development of vaccines targeting to FeLV.关键词
猫白血病病毒/流行状况/进化/突变Key words
feline leukemia virus/epidemic tendency/evolution/mutation分类
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张琳,黄悦妍,郭梦帅,郭立辉,房立春,王珺琨,高晓洁,亓丽红,吴家强..我国部分地区猫白血病病毒的流行状况及env基因的遗传进化分析[J].经济动物学报,2025,29(2):139-145,7.基金项目
国家重点研发计划项目(2023YFD1800301),泰山学者特聘专家工程项目(ts201511069) （2023YFD1800301）
