山东医药2025，Vol.65Issue(3)：40-45,6.DOI:10.3969/j.issn.1002-266X.2025.03.009
基于双样本双向孟德尔随机化的5种自身免疫性疾病与非酒精性脂肪性肝病因果关系分析
Causal relationship between five autoimmune diseases and NAFLD:a two-sample bidirectional Mendelian randomization study
摘要
Abstract
Objective To investigate the causal relationships between five autoimmune diseases such as inflamma-tory bowel disease(IBD),psoriasis(PsO),rheumatoid arthritis(RA),multiple sclerosis(MS),and systemic lupus er-ythematosus(SLE)and non-alcoholic fatty liver disease(NAFLD)using a two-sample bidirectional Mendelian randomiza-tion(MR)analysis,providing genetic evidence for the association between immune-related disorders and NAFLD risk.Methods A two-sample bidirectional MR analysis was performed to assess causal relationships between the five autoim-mune diseases and NAFLD using five regression models:MR Egger regression,weighted median,random-effects inverse-variance weighted(IVW)method,weighted mode,and simple mode.Results IVW analysis revealed a significant causal association between IBD and NAFLD(β=0.046 6,SE=0.015 7,P=0.003),with a positive effect size(OR=1.047 7,95%CI:1.016 0-1.080 5).The simple mode yielded consistent and significant results(β=0.126 6,SE=0.054 1,P=0.021 2),further supporting the robustness of the causal relationship.No significant association was ob-served between RA and NAFLD using IVW(β=0.016 9,SE=0.018 7,P=0.365 8).Analyses for other autoimmune dis-eases were excluded due to insufficient instrumental variable SNPs(<10),which posed risks of statistical under-powering or bias.Conclusion The two-sample bidirectional MR analysis indicates a causal relationship between IBD and NAFLD,suggesting that IBD may increase the risk of NAFLD development.关键词
孟德尔随机化/双样本双向孟德尔随机化/非酒精性脂肪性肝病/免疫性疾病/炎症性肠病/共病现象Key words
Mendelian randomization:two-sample bidirectional Mendelian randomization/non-alcoholic fatty liver disease/immune disease/inflammatory bowel disease/comorbidity分类
临床医学引用本文复制引用
崔娟,陈毅盛,温惠红,曾林琳,闫海震..基于双样本双向孟德尔随机化的5种自身免疫性疾病与非酒精性脂肪性肝病因果关系分析[J].山东医药,2025,65(3):40-45,6.基金项目
广东省中医药局科研项目(20221302,20242066) （20221302,20242066）
广州地区中医药重大科技项目(2025CX018). （2025CX018）
