中国伤残医学2025，Vol.33Issue(6)：80-84,5.DOI:10.13214/j.cnki.cjotadm.2025.006.019
睡眠障碍对糖尿病共病抑郁老年患者炎性指标及认知功能的影响
Effects of Sleep Disorders on Inflammatory Markers and Cognitive Function in Elderly Diabetic Patients with Depression
郭宜文 1周逸琳2
作者信息
- 1. 江西省于都县人民医院老年医学科,江西 赣州 341000
- 2. 江西省赣州市人民医院感染科,江西 赣州 341000
- 折叠
摘要
Abstract
Objective:To explore the effects of sleep disorders on inflammatory indexes and cognitive function in elderly diabetic patients with depression.Methods:The data of 96 elderly diabetic patients with depression patients admitted to Yudu County People's Hospital from February 2021 to December 2023 were retrospectively analyzed,and were divided into control group(n=52)and observation group(n=44)according to the assessment of Pittsburgh Sleep Quality Index(PSQI).PSQI score≥8 points in the observation group and<8 points in the control group.Depression status,sleep disorder,serum inflammatory factor levels and cognitive function were compared between the two groups.Pearson correlation analysis was used to explore the correlation between each index and the occurrence of sleep disorders.Results:The Hamilton Depression Scale-17(HAMD-17)score of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The levels of interleukin-1β and interleukin-6 in observation group were higher than those in control group,with statistical significance(P<0.05).There was no significant difference in tumor necrosis factor-α and C-reactive protein levels between the two groups(P>0.05).The scores of immediate memory,verbal function,attention,visual span,delayed memory and total score in the Repeatable Battery for the Assessmental of Neuropsychological Status(RBANS)scale of the observation group were lower than those of the control group,with statistical significance(P<0.05).Correlation analysis showed that PSQI score was positively correlated with HAMD-17 score,IL-1β level and IL-6 level,and negatively correlated with RBANS score.Conclusion:Sleep disorders are significantly correlated with the aggravation of depressive symptoms,the enhancement of inflammatory response and the decline of cognitive function in elderly patients with depression co-existing with diabetes mellitus.Timely targeted intervention is needed to avoid the aggravation of the disease.关键词
睡眠障碍/糖尿病/抑郁症/认知功能/炎症Key words
Sleep Disorders/Diabetes/Depression/Cognitive Function/Inflammatory分类
医药卫生引用本文复制引用
郭宜文,周逸琳..睡眠障碍对糖尿病共病抑郁老年患者炎性指标及认知功能的影响[J].中国伤残医学,2025,33(6):80-84,5.
