山东医药2025，Vol.65Issue(3)：130-133,149,5.DOI:10.3969/j.issn.1002-266X.2025.03.027
动脉导管未闭对早产儿的影响及其治疗措施研究进展
Impact of PDA on preterm infants and research progress on its therapeutic interventions
摘要
Abstract
Patent ductus arteriosus(PDA)is one of the most common congenital heart diseases in children,with a higher incidence among preterm infants.Due to the immaturity of organ systems in preterm infants,PDA exerts more sig-nificant adverse effects compared with term infants,leading to respiratory and circulatory complications such as pulmonary congestion,pulmonary edema,bronchopulmonary dysplasia,pulmonary hypertension,and Eisenmenger syndrome,pos-ing severe threats to their health.Appropriate and timely treatment is critical to improving the survival rate and quality of life in preterm infants with PDA.Primary therapeutic interventions include symptomatic management,pharmacotherapy,surgical procedures,and interventional therapies.Controlled fluid intake serves as the cornerstone of symptomatic treat-ment,with diuretics administered as needed to reduce cardiac volume overload.Medications such as indomethacin,ibu-profen,and acetaminophen inhibit prostaglandin synthesis to promote ductal closure,demonstrating confirmed efficacy,but their potential adverse effects require careful consideration.For preterm infants with PDA unresponsive to multiple courses of pharmacotherapy and experiencing severe cardiopulmonary compromise,surgical ligation becomes necessary in the absence of contraindications.Surgical approaches include the traditional posterolateral left thoracotomy for ductal liga-tion,minimally invasive left anterior second intercostal incision ligation,and bedside PDA ligation.In recent years,inter-ventional therapies like transcatheter closure have been increasingly utilized for PDA treatment,offering advantages over open surgical ligation by minimizing complications.However,their application in preterm infants with extremely low body weight or gestational age remains technically challenging.Tailoring device selection to the unique anatomical and physio-logical characteristics of preterm infants is essential to enhance procedural success rates.关键词
先天性心脏病/动脉导管未闭/早产儿/支气管肺发育不良Key words
congenital heart disease/patent ductus arteriosus/premature infant/bronchopulmonary dysplasia分类
医药卫生引用本文复制引用
龙庆义,刘思佳,张秋月..动脉导管未闭对早产儿的影响及其治疗措施研究进展[J].山东医药,2025,65(3):130-133,149,5.基金项目
国家自然科学基金资助项目(82060289). （82060289）
