中国伤残医学2025，Vol.33Issue(7)：86-90,95,6.DOI:10.13214/j.cnki.cjotadm.2025.007.019
中草药相关肝损伤的危险因素分析
Analysis of Risk Factors for Herb-Induced Liver Injury
摘要
Abstract
Objective:Based on clinical data,the risk factors of herb-induced liver injury(HILI)were investigated.Methods:Data of 1 387 patients who received Chinese herbal medicine in the 90th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army from January,2004 to August,2024 were retrospectively analyzed,and divided into case group(n=329)and control group(n=658)according to whether HILI occurred.The relevant baseline data of the two groups were collected,and the relevant factors affecting the occurrence of HILI were analyzed by one-way analysis.Logistic regression was included in the one-way analysis for multivariate analysis,so as to explore the risk factors affecting the occurrence of HILI.Results:The results of single factor analysis showed that Sex,age,tumor,white blood cell count,red blood cell count,hemoglobin,neutrophil count,total protein,total bilirubin,direct bilirubin,alanine aminotransferase,glutamyl transpeptide,alkaline phosphatase,total bile acid,cholinesterase,prothrombin time,urea,total cholesterol,triglycerides,low density lipoprotein cholesterol,high density lipoprotein cholesterol,glutamic acid Aminotransferase was associated with the occurrence of HILI(P<0.05).Logistic regression analysis showed that old age,complicated tumor,increased total bilirubin,glutamyltranspeptide,total bile acid and urea were independent risk factors for HILI,while decreased white blood cell count and increased total protein were protective factors for HILI(P<0.05).Conclusion:Old age,complicated tumor,elevation of total bilirubin,glutamyltranspeptide,total bile acid and urea are independent risk factors for HILI.Dynamic monitoring of relevant indicators may be of positive significance for the prevention of HILI.关键词
中草药相关肝损伤/影响因素/危险因素Key words
Herb-induced liver injury/Influence factor/Risk factors分类
医药卫生引用本文复制引用
齐旭鸽,蔡丽蓉,肖扬..中草药相关肝损伤的危险因素分析[J].中国伤残医学,2025,33(7):86-90,95,6.基金项目
福建省科技创新联合资金项目(2024Y9648) （2024Y9648）
联勤保障部队第九〇〇医院2023年度医院科研计划(2023SA02) （2023SA02）
