摘要
Abstract
Objective:To compare the clinicopathological features of patients with proximal and distal early gastric cancer treated by endoscopic submucosal dissection(ESD).Methods:Data of 180 patients with early gastric cancer who received ESD treatment and underwent postoperative pathological examination in the Second Affiliated Hospital of Zhengzhou University from April 2021 to April 2024 were retrospectively analyzed,and were divided into the distal lesion group(n=124)and the proximal lesion group(n=56)according to different lesion locations.The clinical data(gender,age,past history)and pathological data(tumor diameter,endoscopic classification,depth of invasion,tissue differentiation type,lymphatic vessel invasion,venous invasion,Snail protein expression,e-cadherin expression)of the two groups were compared,and the ESD healing status,lymph node metastasis risk and follow-up recurrence rate of the two groups were compared.Results:The tumor diameter of the proximal lesion group was smaller than that of the distal lesion group,the proportions of superficial flat type,submucosal infiltration,Snail protein high expression rate and E-cadherin low expression rate under endoscopy were 30.36%,21.43%,75.00%and 67.86%,respectively,which were higher than 9.68%,8.06%,29.84%and 33.87%of the remote lesion group,the differences were statistically significant(P<0.05).The complete remission rate of ESD and recurrence rate in the proximal lesion group were 69.64%and 1.78%,respectively,compared with 78.23%and 0.00%in the distal lesion group,there were no significant differences(P>0.05);there was no significant difference in the risk of lymph node metastasis between the two groups(P>0.05).Conclusion:Early gastric cancer with distal lesions has larger tumor diameter and less submucosal invasion,while early gastric cancer with proximal lesions has more superficial flat type,higher Snail expression and lower E-cadherin expression.There were no significant differences in ESD resection effect,lymph node metastasis risk and follow-up recurrence rate of early gastric cancer in different lesion locations.关键词
早期胃癌/胃远端病变/胃近端病变/内镜黏膜下剥离术/临床特征/病理特征Key words
Early gastric cancer/Distal gastric lesions/Proximal gastric lesions/Endoscopic submucosal dissection/Clinical features/Pathological features分类
医药卫生
