实用肿瘤杂志2025，Vol.40Issue(2)：167-171,5.DOI:10.13267/j.cnki.syzlzz.2025.026
基于MVCT图像引导放疗的分次间和分次内头颈部肿瘤外扩边界研究
Inter-and intra-fractional extension of head and neck tumors based on MVCT image-guided radiotherapy
摘要
Abstract
Objective To investigate the inter-and intra-fractional expansion boundaries of head and neck tumors treated with helical tomotherapy(HT)under the guidance of mega voltage CT(MVCT).Methods Ten patients with head and neck tumors treated with HT at Sun Yat-sen University Cancer Center from December 2017 to February 2018 were selected.Each patient underwent MVCT scan before treatment once a week.After image registration,the inter-fractional error data were recorded and corrected,and the residual error data were scanned and registered again.The intra-fractional errors were obtained,and the planning target volume(PTV)margin was calcu-lated.Results Each patient was scanned 5 times for a total of 50 times,and the setup errors in the left-right(X-axis),anterior-posterior(Y-axis),and superior-inferior(Z-axis)directions were obtained.The average inter-fractional error in the Z axis was 2.80 mm.There were significant differences in the inter-fractional error and the residual error after online calibration in the three directions(all P<0.05).There were no significant differences in the intra-fractional error and the residual error in the three directions(all P>0.05).The PTV margins for the inter-fractional errors in the X-,Y-,and Z-axis directions were 2.279,2.447,and 1.805 mm,respectively,while the PTV margins for the residual errors were 0.853,0.963,and 0.917 mm,and the PTV margins for the intra-fractional errors were 1.015,0.979,and 0.710 mm.Conclusions The inter-fractional setup errors in the Z direction were generally large.The image guidance before each radiotherapy can greatly reduce the PTV margin of radiotherapy plan.The residual errors after image-guided radiotherapy and the intra-fractional errors should be considered comprehensively in the planning of head and neck radiotherapy.关键词
头颈部肿瘤/螺旋断层调强放疗/外扩边界/分次间误差/分次内误差Key words
head and neck tumors/helical tomotherapy/external expansion boundary/inter-fractional error/intra-fractional error引用本文复制引用
李宗泰,林志悦,姚文燕,迟锋,许森奎..基于MVCT图像引导放疗的分次间和分次内头颈部肿瘤外扩边界研究[J].实用肿瘤杂志,2025,40(2):167-171,5.基金项目
广东省医学科学技术研究基金(A2017613) （A2017613）
广东省食管癌研究所科技计划(Q202107) （Q202107）
中山大学肿瘤防治中心青年优创项目(PT21020101) （PT21020101）
