食管疾病2025，Vol.7Issue(1)：9-15,7.DOI:10.15926/j.cnki.issn2096-7381.2025.01.002
M2型巨噬细胞及其相关基因FOLR2在食管鳞癌中的研究
Study on M2 Macrophages and Their Associated Gene FOLR2 in Esophageal Squamous Cell Carcinoma
上官峰 1李新阳 1王玉华1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院,中国 洛阳,471023
- 折叠
摘要
Abstract
Objective To investigate the infiltration or expression levels of M2 macrophages and their related key genes in esophageal squamous cell carcinoma(ESCC),and to assess their impact on the prognosis of ESCC patients.Methods The ESCC gene expression matrix was obtained from the TCGA database.Basingon Rstudio,the infiltration level of M2 macrophages in ESCC tissues was assessed with the immune infiltration CIBERSORT package,and the key genes related to M2 macrophages were identified through difference analysis with the Limma package.Finally,the influence of M2 macrophages infiltration level and related keys on the prognosis of ESCC patients was evaluated by survⅣal package.Results Studies have shown that there are differences in the infiltration levels of 22 types of immune cells in ESCC tissue,among which M2 macrophages have relatively higher infiltration levels and are significantly correlated with poorer survival rates.FOLR2,as a key gene,is highly expressed in ESCC tissues and is closely related to pathological grading,clinical staging,TP53 mutation and poor prognosis.Single-cell data analysis suggests that FOLR2 is mainly expressed in macrophages.Conclusion M2 macrophages play an important role in ESCC studies,and FOLR2 can be used as an effective biomarker and potential therapeutic target for ESCC.关键词
食管鳞癌/M2型巨噬细胞/FOLR2/预后Key words
esophageal squamous cell carcinoma/M2 macrophages/FOLR2/prognosis分类
临床医学引用本文复制引用
上官峰,李新阳,王玉华..M2型巨噬细胞及其相关基因FOLR2在食管鳞癌中的研究[J].食管疾病,2025,7(1):9-15,7.
