食管疾病2025，Vol.7Issue(1)：28-34,7.DOI:10.15926/j.cnki.issn2096-7381.2025.01.005
一种多功能仿生纳米颗粒对食管癌细胞的作用研究
Study on the Impact of a Multifunctional Biomimetic Nanoparticle on Esophageal Cancer Cells
段智康 1肖倩文 1杨玉坤 1张泽群 1姚俊1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院,中国 洛阳,471023
- 折叠
摘要
Abstract
Objective To fabricate a biomimetic nanoparticle,that is enveloped by the membrane of tumor cells and to explore the photothermal effect and its impact on esophageal cancer cells.Methods Encapsulation of esophageal cancer cell membrane onto nano core surface using liposome extruder to synthe-size nanoparticles,CCM@PLGA-PEG-OXA-ICG(CCM@POI NPs).The morphology,particle size,Zeta potential,and other physical and chemical characteristics of this nanoparticle were analyzed.Additionally,the photothermal effect and temperature stability under 808nm near-infrared laser irradiation were investigated.Its impact on the proliferation,migration,and invasion ability of esophageal cancer cells.was studied.Results The CCM@POI NPs nanoparticles were successfully synthesized,which exhibit rapid heating capa-bilities upon 808nm near-infrared laser irradiation and demonstrate excellent photothermal cycling perform-ance.The combined application of photothermal therapy significantly suppresses the proliferation,migration,and invasion of esophageal cancer cells.Conclusion The combination of CCM@POI NPs biomimetic nan-oparticles and photothermal therapy can enhance anti-tumor effects and provide new ideas for the clinical treatment of esophageal cancer.关键词
纳米颗粒/食管癌/光热治疗/药物载体/仿生微纳技术Key words
nanoparticles/esophageal cancer/photothermal Therapy/drug carrier/biomimetic micronano technology分类
临床医学引用本文复制引用
段智康,肖倩文,杨玉坤,张泽群,姚俊..一种多功能仿生纳米颗粒对食管癌细胞的作用研究[J].食管疾病,2025,7(1):28-34,7.
