兰州大学学报（医学版）2025，Vol.51Issue(2)：10-16,31,8.DOI:10.13885/j.issn.1000-2812.2025.02.002
2型糖尿病合并高血压患者发生脑血管事件风险的巢式病例对照研究
Risk factors of cerebrovascular events in patients with type 2 diabetes mellitus and hypertension:a nested case-control study
摘要
Abstract
Objective To evaluate the association between hypertension and risk of cerebrovascular events(CVE)among patients with type 2 diabetes mellitus(T2DM).Methods A nested case-control study was con-ducted based on a cohort of inpatients with T2DM from The Second Hospital of Lanzhou University from Jan-uary to December 2018.As of Dec.31,2023,a total of 54 incident cases of CVE were identified,and 162 matched controls were randomly selected among the cohort subjects who were free of CVE.The matching criteria were age(within 3 years),gender,and date of admission.The variables with non-zero coefficients,which were screened out by LASSO regression,were included in a binary Logistic regression to estimate the odd ratio(OR)and 95%confidence interval(CI).Results Patients with T2DM and hypertension or never were associated with risk of CVE(OR=3.03,95%CI:[1.26,7.32]).Additionally,coronary heart disease(OR=5.66,95%CI:[1.91,16.83]),duration more than 5 years of T2DM(OR=6.41,95%CI:[1.57,35.07]),inadequate diastolic blood pressure(OR=2.70,95%CI:[1.32,5.52])and inadequate high-density lipoprotein(OR=2.33,95%CI:[1.11,4.90])were identified as independent risk factors for CVE in patients with T2DM(P<0.05).Conclusion Patients with T2DM and hypertension are more likely to have CVE.Additionally,coronary heart disease,increasing duration more than 5 years of T2DM,inadequate diastolic blood pressure and inadequate high-density lipoprotein are independent risk factors for CVE in T2DM.This study can offer a more comprehensive reference for the holistic management of stroke risk in T2DM patients.关键词
2型糖尿病/高血压/脑血管事件/巢式病例对照研究/共病管理/冠心病/高密度脂蛋白Key words
type 2 diabetes mellitus/hypertension/cerebrovascular events/nested case-control study/multi-morbidity management/coronary heart disease/high-density lipoprotein分类
临床医学引用本文复制引用
曾文宝,康静,贺文超,姚思琪,潘建武,张正义..2型糖尿病合并高血压患者发生脑血管事件风险的巢式病例对照研究[J].兰州大学学报（医学版）,2025,51(2):10-16,31,8.基金项目
甘肃省科技计划资助项目(23YFA0039) （23YFA0039）
兰州大学教育研究资助项目(071100135) （071100135）
