陕西中医2025，Vol.46Issue(4)：476-480,5.DOI:10.3969/j.issn.1000-7369.2025.04.009
宁瘿方联合小剂量甲巯咪唑治疗Graves病疗效及对患者促炎细胞因子的影响
Efficacy of Ningying decoction combined with low-dose methimazole in the treatment of newly diagnosed Graves'disease and its effect on pro-inflammatory cytokines in patients
摘要
Abstract
Objective:To evaluate the clinical efficacy and safety of Ningying decoction combined with low-dose methimazole in the treatment of newly diagnosed Graves'disease,as well as its effects on pro-inflammatory cyto-kines in patients.Methods:A total of 120 patients newly diagnosed with Graves'disease were recruited for this study and randomly divided into two groups,with 60 patients in each group.The experimental group received Ningying de-coction combined with low-dose methimazole(10 mg),while the control group received a conventional dose of me-thimazole(20～40 mg).All patients were treated continuously for 12 weeks,during which thyroid function indicators(FT3,FT4,TSH),thyroid-related antibodies(TRAb,TPOAb,TgAb),pro-inflammatory cytokines including inter-leukin-1β(IL-1β)and interleukin-6(IL-6),as well as self-reported depression and anxiety scales(SDS,SAS)scores and the 36-item Short Form Health Survey(SF-36)scores were monitored.Additionally,safety indicators including liver function and complete blood count were assessed.Results:A total of 9 patients dropped out,and ultimately,111 patients were included in the statistical analysis.After 12 weeks of treatment,the total effective rate of experimental group was significantly higher than that of control group(P<0.05).The improvement of thyroid function indexes in the two groups was similar(P>0.05).Thyroid related antibodies were significantly decreased,SDS,SAS and SF-36 scores were improved,IL-1βand IL-6 levels were decreased,and the incidence of liver function injury and granulope-nia adverse events were lower in experimental group(all P<0.05).Conclusion:In the treatment of newly diagnosed Graves'disease,the combination of Ningying decoction with low-dose methimazole demonstrates superior clinical ef-ficacy and safety compared to conventional-dose methimazole monotherapy,and it can reduce the levels of pro-inflam-matory cytokines IL-1βand IL-6.关键词
Graves病/宁瘿方/甲巯咪唑/促甲状腺抗体受体/白介素-1β/白介素-6Key words
Graves'disease/Ningying decoction/Methimazole/TRAb/IL-1β/IL-6分类
临床医学引用本文复制引用
黄昱钦,李青春,柳国斌,陶枫,王雪菲,陈易..宁瘿方联合小剂量甲巯咪唑治疗Graves病疗效及对患者促炎细胞因子的影响[J].陕西中医,2025,46(4):476-480,5.基金项目
上海市科技计划项目(23Y11921500) （23Y11921500）
上海市嘉定区卫健委中医药科研面上项目(2024-KY-ZYY-06) （2024-KY-ZYY-06）
