陕西中医2025，Vol.46Issue(4)：490-494,5.DOI:10.3969/j.issn.1000-7369.2025.04.012
哈氏育阴汤治疗肝肾阴虚型卵巢储备功能减退疗效及对患者血管生成因子的影响
Efficacy of Ha's Yuyin decoction on diminished ovarian reserve with liver-kidney yin deficiency and its influence on angiogenesis factor
摘要
Abstract
Objective:To observe the clinical efficacy of diminished ovarian reserve(DOR)with liver-kidney yin deficiency treated by Ha's Yuyin decoction,and its effect on angiogenesis factor.Methods:According to the inclusion and exclusion criteria,60 patients with liver-kidney yin deficiency DOR were selected and randomly divided into treat-ment group(30 cases)and control group(30 cases).The treatment group was treated with Ha's Yuyin decoction,while the control group with Kuntai capsules.After three months,the clinical efficacy of the two groups were ob-served.The changes of TCM syndrome score,serum hormone level(bFSH,bE2,AMH,bFSH/bLH),AFC,angio-genesis factor(HIF-1α,VEGF,Ang-1,Ang-2)before and after treatment were observed and compared between the two groups.Results:Finally 56 cases were completed,29 cases in the treatment group and 27 cases in the control group.The total treatment response rate in the treatment group(89.66%)was significantly higher than that in the control group(74.07%)(P<0.05).TCM syndrome score,bFSH and HIF-1αdecreased after treatment,while bE2 increased after treatment(all P<0.05).After treatment,AMH,AFC,VEGF,Ang-2 and Ang-1 were increased,while bFSH/bLH were decreased(all P<0.05).Moreover,the treatment group was better than the control group in improving TCM syndrome score,bFSH,bFSH/bLH,AMH,AFC,VEGF,Ang-2 and Ang-1(all P<0.05).Conclusion:Ha's Yuyin decoction has a significant therapeutic effect on DOR with liver-kidney yin deficiency,and can improve the clinical symptoms of traditional Chinese medicine,regulate reproductive hormones and AMH levels,increase AFC,regulate angiogenic factors,thereby improving ovarian reserve.关键词
卵巢储备功能减退/血管生成因子/哈氏育阴汤/坤泰胶囊/中医证候评分/抗缪勒管激素Key words
Diminished ovarian reserve/Angiogenesis factor/Ha's Yuyin decoction/Kuntai capsule/TCM syndrome score/AMH分类
医药卫生引用本文复制引用
许凯凯,马静,张晗,褚梦圆,刘佳宁,李白玉,杨嘉琪,闫颖..哈氏育阴汤治疗肝肾阴虚型卵巢储备功能减退疗效及对患者血管生成因子的影响[J].陕西中医,2025,46(4):490-494,5.基金项目
全国中医学术流派传承工作室建设项目(LPGZS2012-04) （LPGZS2012-04）
天津市卫健委中医中西医结合科研项目(2023021) （2023021）
天津市教委科研计划项目(2023ZD031,2021ZD015) （2023ZD031,2021ZD015）
