陕西中医2025，Vol.46Issue(4)：499-503,5.DOI:10.3969/j.issn.1000-7369.2025.04.014
益气养血方治疗非小细胞肺癌根治术后咳嗽疗效及对患者炎症因子的影响
Effect of Yiqi Yangxue prescription on cough after radical treatment of non-small cell lung cancer and its influence on inflammatory factors
摘要
Abstract
Objective:Based on the theory of"Tongtiao Sanjiao"to explore the therapeutic effect of Yiqi Yangx-ue prescription on cough after radical surgery in patients with non-small cell lung cancer(NSCLC).Methods:150 pa-tients with cough after undergoing radical resection for NSCLC were selected.By random coin tossing method,the participants were divided into observation group(digit side,75 cases)and control group(flower side,75 cases).Both groups were treated with conventional cough relief and phlegm resolving treatment.On this basis,the control group was additionally given montelukast sodium tablets,while the observation group was added with Yiqi Yangxue pre-scription on the basis of the control group.The clinical efficacy,TCM syndromes scores,pulmonary ventilation func-tion indicators[forced vital capacity(FVC),peak expiratory flow(PEF),proportion of forced expirations in the first second to forced vital capacity(FEV1/FVC),lung carbon monoxide diffusing capacity(DLCO),maximum mid-ex-piratory flow(MMEF),and maximum voluntary ventilation(MVV)],inflammatory factors[high-mobility group box-1 protein(HMGB1),CXC chemokine ligand 10(CXCL10)and serum amyloid A(SAA)]were compared be-tween the two groups before and after treatment,and the occurrence of adverse reactions during treatment was recor-ded.Results:After the end of treatment,the efficacy rate of the treatment in the observation group was markedly su-perior to that of the control group,and both the relapse rate and the scores for TCM symptoms were considerably lower in the observation group compared to the control group(all P<0.05).The levels of pulmonary ventilation function indicators FVC,PEF,FEV1/FVC,DLCO,MMEF and MVV in the two groups of patients were significantly improved compared with those before treatment,the enhancements observed in the observation group were notably more pronounced and surpassed those of the control group with statistical significance(all P<0.05).The levels of inflammatory factors HMGB1,CXCL10 and SAA in two groups were significantly lower than before treatment,and the observation group was lower than the control group(all P<0.05).There was no significant difference in the in-cidence of adverse reactions between groups(P>0.05).Conclusion:Yiqi Yangxue prescription has significant cura-tive effect on cough after radical treatment of NSCLC patients,which can effectively reduce TCM syndrome scores,enhance lung ventilation function,reduce inflammation,and has good drug safety.关键词
非小细胞肺癌/通调三焦/益气养血方/术后咳嗽/疗效/炎症因子Key words
Non-small cell lung cancer/Tongtiao Sanjiao/Yiqi Yangxue prescription/Postoperative cough/Efficacy/Inflammatory factor分类
医药卫生引用本文复制引用
朱鹏飞,蒋国鹏,张云杰,宿广峰..益气养血方治疗非小细胞肺癌根治术后咳嗽疗效及对患者炎症因子的影响[J].陕西中医,2025,46(4):499-503,5.基金项目
山东省自然科学基金资助面上项目(ZR2021MH297) （ZR2021MH297）
