实用中医内科杂志2025，Vol.39Issue(3)：23-26,后插1,5.DOI:10.13729/j.issn.1671-7813.Z20240729
18β-甘草次酸对失血性休克大鼠肺组织损伤及炎症因子TNF-α、IL-1β的影响
Effects of 18β-Glycyrrhetinic Acid on Lung Injury and Inflammatory Cytokines TNF-α and IL-1β In Hemorrhagic Shock Rats
摘要
Abstract
Objective To investigate the effects of 18β-glycyrrhetinic acid(18 β-glycyrrhetinic acid,18 β-gly)on lung in-jury and inflammatory cytokines TNF-α and IL-1 β in hemorrhagic shock rats.Methods SD Female rats were randomLy divided into 5 groups:sham operation group,model group,18 β-Gly/low dose group,18 β-Gly/medium dose group and 18 β-Gly/high dose group.After 18 β-glycyrrhetinic acid pretreatment,the rat model of hemorrhagic shock was made by femoral artery bloodlet.The wet/dry ratio of lung tissue,pathological morphological changes of lung tissue,and expression of inflammatory factors TNF-α and IL-1 β in blood and alveolar lavage fluid were detected.Results Compared with model group,the lung wet/dry ratio in 18β-Gly/high-dose group(4.409±0.062)was significantly decreased(P＜0.05).The expressions of TNF-α and IL-1 β in blood and alveolar lavage fluid of 18 β-Gly/medium dose group and 18 β-Gly/high dose group were significantly de-creased(P＜0.05).HE showed that pathological damage was significantly reduced in the 18 β-Gly/medium dose and 18 β-Gly/high dose groups compared with the model group.Conclusion 18 β-Gly can alleviate pulmonary edema and pathological damage of lung tissue in hemorrhagic shock rats,and decrease the expression of inflammatory cytokines TNF-α and IL-1 β in blood and alveolar lavage fluid.关键词
甘草次酸/失血性休克/急性肺损伤/炎症因子Key words
glycyrrhetinic acid/hemorrhagic shock/acute lung injury/inflammatory factors分类
医药卫生引用本文复制引用
姜现瑞,梁悦,王欣瑶,刘婧,贺超流,包越,盖倩,张娟娟..18β-甘草次酸对失血性休克大鼠肺组织损伤及炎症因子TNF-α、IL-1β的影响[J].实用中医内科杂志,2025,39(3):23-26,后插1,5.基金项目
国家级大学生创新训练计划项目(202310740056) （202310740056）
甘肃省高等学校创新基金项目(2021A-119) （2021A-119）
河西学院校长基金青年科研项目(QN2023006) （QN2023006）
甘肃省大学生创新训练计划项目(S202310740006) （S202310740006）
