兰州大学学报（医学版）2025，Vol.51Issue(2)：60-65,6.DOI:10.13885/j.issn.1000-2812.2025.02.008
NAFLD可促进寻常性银屑病的发生:基于双向孟德尔随机化研究
NAFLD promotes the development of psoriasis vulgaris:a study based on bidirectional Mendelian randomization
摘要
Abstract
Objective To explore the potential bidirectional causal relationship between non-alcoholic fatty liv-er disease and psoriasis vulgaris using a two-sample Mendelian randomization(MR)approach.Methods Sin-gle nucleotide polymorphism(SNP)information of the two samples was obtained from publicly available genome-wide association analysis databases,and suitable SNPs screened as instrumental variables.The causal relationship between the two samples was analyzed by two-way MR analysis using inverse variance weight-ing,Egger regression,weighted median and weighted mode,supplemented by various sensitivity analyses to calibrate the results.Results Forward MR analysis revealed that the inverse variance weighting method and the weighted median method showed a significant causal effect of nonalcoholic fatty liver disease on psoriasis vulgaris(both P<0.05),whereas the results of reverse MR did not support reverse causality.The MR-pleiotro-py function and MR-PRESSO test revealed no horizontal pleiotropy(P>0.05),Cochran's Q test revealed no heterogeneity(P>0.05),and the leave-one-out sensitivity analysis proved the stability of the MR findings.Conclusion MR analysis revealed a positive causal relationship between non-alcoholic fatty liver disease and psoriasis vulgaris.关键词
非酒精性脂肪性肝病/寻常性银屑病/银屑病/孟德尔随机化分析/因果关系Key words
non-alcoholic fatty liver disease/psoriasis vulgaris/psoriasis/Mendelian randomization analysis/causal relationship分类
临床医学引用本文复制引用
汪彦平,张惠芳,马小彤,王慧敏,陈兆峰..NAFLD可促进寻常性银屑病的发生:基于双向孟德尔随机化研究[J].兰州大学学报（医学版）,2025,51(2):60-65,6.基金项目
甘肃省联合科研基金重大资助项目(No.23JRRA1487) （No.23JRRA1487）
