兰州大学学报（医学版）2025，Vol.51Issue(2)：66-74,87,10.DOI:10.13885/j.issn.1000-2812.2025.02.009
膳食模式与代谢相关脂肪性肝病的关联性研究
Association between dietary patterns and metabolic dysfunction-associated fatty liver disease
摘要
Abstract
Objective Based on the data from the National Health and Nutrition Examination Survey,this study aimed to extract the dietary patterns among U.S.adults and analyze their associations with metabolic dysfunction-associated fatty liver disease(MAFLD).Methods Adults over 20 years old from three datasets of National Health and Nutrition Examination Survey during 2013-2020 were selected as research subjects.Principal component analysis was employed to extract dietary patterns.Weighted Logistic regression models,trend tests,and weighted restricted cubic spline models with four knots were applied to analyze the associa-tions and dose-response relationships between various dietary patterns and MAFLD.Subgroup analyses were conducted according to gender and age.Results A total of 6 621 research subjects were included,and four di-etary patterns were extracted.After adjusting for 14 influencing factors,the score of the Vegetable and Oils pattern was linearly inversely associated with the risk of MAFLD(OR=0.84,95%CI:[0.78,0.90];P for overall trend<0.05,P for non-linearity>0.05).The scores of the Low Solid Fat and Refined Grains pattern and the Milk and Whole Grains pattern showed non-linear inverse associations with the risk of MAFLD(OR=0.82,95%CI:[0.74,0.92],OR=0.92,95%CI:[0.85,0.99];Pfor overall trend<0.05,Pfor non-linearity<0.05).The association between the score of the Tomato and Legume Protein pattern and the risk of MAFLD was not statistically significant(OR=0.97,95%CI:[0.88,1.06];Pfor overall trend>0.05).The results of subgroup analyses by gender and age were affected by the mixing effects among food components in dietary patterns and population preferences,showing certain differ-ences.Conclusion Except for the Tomato and Legume Protein pattern,the other three dietary patterns may all serve as protective factors against the risk of MAFLD.The results of this study showed differences in gen-der and age.关键词
膳食模式/代谢相关脂肪性肝病/主成分分析/限制性立方样条/美国国家健康与营养调查Key words
dietary patterns/metabolic dysfunction-associated fatty liver disease/principal component analy-sis/restricted cubic spline/National Health and Nutrition Examination Survey分类
预防医学引用本文复制引用
贾佳,刘婧,桑晨,陈浩,王敏珍..膳食模式与代谢相关脂肪性肝病的关联性研究[J].兰州大学学报（医学版）,2025,51(2):66-74,87,10.基金项目
河北省糖尿病基础医学研究重点实验室项目(KF2023-02) （KF2023-02）
