妇儿健康导刊2025，Vol.4Issue(6)：30-34,5.DOI:10.3969/j.issn.2097-115X.2025.06.004
剪接因子SRSF3参与宫颈癌及卵巢癌发病机制的研究进展
Research progress of splicing factor SRSF3 in the pathogenesis of cervical and ovarian cancer
张梅美 1张子瑶 1陈丽竹 1易金玲1
作者信息
- 1. 新疆医科大学第五附属医院,新疆 乌鲁木齐 830011
- 折叠
摘要
Abstract
Alternative splicing is a key gene expression regulation mechanism in the human body,playing a crucial role in normal development.Alternative splicing disorders are closely related to many diseases.SRSF3 is the smallest member of the serine/arginine-rich protein(SR)family.SRSF3 serves as a key splicing factor,participating in the development and progression of various diseases and tumors.Its dysregulation may lead to disruption of normal cell functions.This review summarizes research progress of SRSF3 in the pathogenesis of cervical and ovarian cancer,including how SRSF3 modifies the cell biological behavior of cervical cancer cells through alternative splicing and participates in the regulation of human papilloma virus transcription in the pathogenesis of cervical cancer,as well as the role of SRSF3 in staging and pathogenesis of ovarian cancer.These studies provide new directions for the study of the pathogenesis of gynecologic tumors,the discovery of related tumor markers,and the identification of therapeutic targets.关键词
SRSF3/可变剪接/妇科肿瘤/发病机制/宫颈癌/卵巢癌Key words
SRSF3/Alternative splicing/Gynecological tumor/Pathogenesis/Cervical cancer/Ovarian cancer分类
临床医学引用本文复制引用
张梅美,张子瑶,陈丽竹,易金玲..剪接因子SRSF3参与宫颈癌及卵巢癌发病机制的研究进展[J].妇儿健康导刊,2025,4(6):30-34,5.
