摘要
Abstract
Objective To analyze the incidence and mortality of colorectal cancer in China in 1990 and 2021 and the related risk factors based on the Global Burden of Disease(GBD)2021 database.Methods The incidence and mortality of colorectal cancer in the overall population and different subgroups(age and sex)in China in 1990 and 2021 were analyzed based on the GBD 2021 database.A risk fac-tor attribution analysis for colorectal cancer was performed.Results In 2021,the incidence rate and age-standardized incidence rate of colorectal cancer in China were 46.27/105 and 19.04/105,respectively,and increased by 243.76%and 65.13%,compared to those in 1990.In 2021,the mortality rate and age-standardized mortality rate were 19.33/105 and 13.63/105,respectively.The mortality rate in 2021 in-creased by 90.63%compared to that in 1990,while the age-standardized mortality rate decreased by 12.01%.The highest incidence rate of colorectal cancer in China in 2021 was noted in the 85-89 years age group at 314.58/105,and the highest mortality rate was in the 90-94 years age group at 264.87/105.The incidence and mortality rates of males were higher than those of females in all age groups.In 2021,the population-attributable fraction was the highest for low dairy intake at 18.52%,followed by low grain intake and high red meat intake.Among males,the population-attributable fractions for alcohol consumption,smoking,and high fasting blood glucose were significantly higher than those among females,and the population-attributable fractions for low dairy intake and low calcium intake were significantly lower than those among females.The age-standardized incidence rate of colorectal cancer in China has been higher than the global average since 2011,while the age-standardized mortality rate is on par with the global average.Conclusions From 1990 to 2021,the incidence and mortality rates of colorectal cancer in China have continued to rise.This trend may be related to modifiable risk factors such as diet,insufficient physical activity,and obesity.Addressing these risk factors through public health interventions and strengthening colorectal cancer screening programs are crucial for reducing the burden of colorectal cancer in China.关键词
结直肠癌/发病率/死亡率/危险因素Key words
colorectal cancer/incidence rate/mortality rate/risk factors
