武警医学2025，Vol.36Issue(3)：185-189,196,6.
消化内镜OLGA分级联合血清miR-760对幽门螺杆菌阳性慢性萎缩性胃炎癌变的诊断效能
Efficacy of OLGA grading of digestive endoscopy combined with serum miR-760 in diag-nosis of canceration of Hp-positive chronic atrophic gastritis
高丽 1阎瑞峰 1阚卫军1
作者信息
- 1. 030006 太原,武警山西总队医院内二科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of the combined use of endoscopic OLGA grading and serum miR-760 in the diagnosis of canceration of Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods According to the results of endoscopic di-agnosis and histopathological examination,100 patients with Hp-positive CAG admitted to Shanxi Provincial Corps Hospital of Chinese People's Armed Police Force from September 2022 to September 2023 were divided into CAG group(61 cases)and canceration group(39 cases).The clinical data,digestive endoscopy OLGA grading,serum miR-760,and the score of the new gastric cancer screening scoring system were compared between the two groups.Multivariate logistic regression analysis was used to explore the independent risk factors related to Hp-positive CAG cancer,and receiver operating characteristic curve(ROC)was used to analyze the value of different schemes in the diagnosis of Hp-positive CAG cancer risk.Results The severity of Hp infection in the canceration group was higher than that in the CAG group,and the scores of endoscopic OLGA and the new gastric cancer screening scoring system were higher than those in the CAG group,while the miR-760 level was lower than that in the CAG group(P<0.05).Multivariate logistic regression analysis showed that the OLGA grade IV and the increased score of the new gastric cancer screening scoring system were independent risk factors for Hp-positive CAG cancer,while the increased level of miR-760 was an independent protective factor for the carcinogenesis of Hp-posi-tive CAG(P<0.05).ROC curve showed that the combined use of endoscopic OLGA grading and serum miR-760 was significantly higher than endoscopic OLGA grading and serum miR-760 alone(P<0.05).The AUC of the combined use of the OLGA classification of diges-tive endoscopy and serum miR-760 was significantly higher than that of the new gastric cancer screening scoring system(P<0.05).The consistency analysis of Kappa value showed that the diagnostic accuracy of Hp-positive CAG canceration using the combined method of en-doscopic OLGA classification and serum miR-760 was 91.67%in clinical practice,with a Kappa value of 0.805(95%CI:0.552-1.058)(P<0.05).Conclusions The combination of the OLGA grading of digestive endoscopy and serum miR-760 can significantly improve the diagnostic efficacy of canceration in Hp-positive CAG pa-tients,providing important reference information for clinical precision identification of high-risk populations,precise intervention,and re-duction of the incidence of gastric cancer.关键词
消化内镜OLGA分级/miR-760/Hp阳性慢性萎缩性胃炎/癌变/诊断效能Key words
digestive endoscopy OLGA grading/miR-760/Hp-positive chronic atrophic gastritis/canceration/diagnostic efficiency分类
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高丽,阎瑞峰,阚卫军..消化内镜OLGA分级联合血清miR-760对幽门螺杆菌阳性慢性萎缩性胃炎癌变的诊断效能[J].武警医学,2025,36(3):185-189,196,6.
