汕头大学医学院学报2025，Vol.38Issue(1)：15-21,7.DOI:10.13401/j.cnki.jsumc.2025.01.004
1 925例乳腺癌患者临床病理特征回顾性分析
Retrospective analysis of clinical pathological characteristics of 1 925 breast cancer patients
李宇珊 1朱彦 2贺丽芳 3方梓昊 1梁娣 1林佳佳 1李从铸2
作者信息
- 1. 汕头大学公共卫生学院,广东 汕头 515063
- 2. 汕头大学医学院附属肿瘤医院妇瘤科,广东 汕头 515041
- 3. 汕头大学医学院附属肿瘤医院乳腺中心,广东 汕头 515041
- 折叠
摘要
Abstract
Objective:To investigate the clinical pathological characteristics of breast cancer patients admitted to the Cancer Hospital of Shantou University Medical College,and to provide a reference basis for local breast cancer prevention and treatment.Methods:Clinical data of 1,925 female breast cancer patients who were diagnosed and received comprehensive treatment at the Cancer Hospital of Shantou University Medical College between January 2014 and January 2020 were retrospectively analyzed.The patients were divided into 3 groups based on the age at diagnosis:the young group(≤40 years old),the middle-aged group(>40-<60 years old),and the elderly group(≥60 years old),and the differences in clinicopathologic features among patients of different age groups were compared.Results:The mean age at diagnosis of the 1,925 breast cancer patients was 53 years old,with a high prevalence of 34%between 50 and 60 years of age.90.0%of the patients had an education level of secondary school and below.The overweight and obesity rate among menopausal patients was 45.2%.Pathological types were mainly invasive ductal carcinoma,accounting for 82.8%,and T2 stage tumors were the most common.Early breast cancer(stage 0-II)accounted for 67.0%,but the tumor was highly invasive,G3 stage tumors accounted for 57.8%,and Ki-67 high-expression tumors accounted for 72.3%.Luminal B type was the most common in molecular typing,accounting for 48.6%.The differences between different age groups in terms of tumor histological type,tumor size,histological grading,HER-2 expression,Ki-67 index,and CEA level were statistically significant(P<0.05).The proportion of invasive ductal carcinoma decreased and the proportion of carcinoma in situ and other carcinomas increased with age.The proportion of Tis/T1 stage and T3 stage tumors was high in the young group,and the proportion of T4 stage tumors was high in the old group.The proportion of low-differentiated tumors was high in the young group,and the proportion of high-differentiated tumors was high in the old group.The middle-aged group had a high rate of HER-2 positivity,the young group had a high proportion of patients with high Ki-67 index,and the elderly group had a high proportion of high CEA levels.Conclusion:The present study population had a low level of education,a high percentage of postmenopausal obesity and overweight,a low percentage of early-stage tumors at first diagnosis,and a high level of tumor aggressiveness.关键词
乳腺肿瘤/女性/年龄/临床病理Key words
breast tumors/women/age/clinical pathology分类
临床医学引用本文复制引用
李宇珊,朱彦,贺丽芳,方梓昊,梁娣,林佳佳,李从铸..1 925例乳腺癌患者临床病理特征回顾性分析[J].汕头大学医学院学报,2025,38(1):15-21,7.
