同位素2025，Vol.38Issue(2)：141-146,6.DOI:10.7538/tws.2024.youxian.084
基于NEPTIS Perform模块的Aβ显像剂18F-AV45的自动化合成
Automated Synthesis of Aβ Imaging Agent 18F-AV45 Based on NEPTIS Perform Module
王强 1唐毅 1张月颖 1王方洋1
作者信息
- 1. 陆军军医大学大坪医院核医学科,重庆 400042
- 折叠
摘要
Abstract
To meet the clinical application requirements,the Aβ-Amloid imaging agent 18F-AV45 was synthesized automatically using NEPTIS perform synthesis module.In the pre-written program,the AV105 was used as precursor to obtain the 18F-intermediate through nucleophilic substitution reaction with 18F-,followed by hydrolysis with hydrochloric acid,neutralization with base to obtain the crude product of 18F-AV45,which was next purified by solid-phase extraction and semi-preparative high-performance liquid chromatography(HPLC).Finally,18F-AV45 injection solution was obtained through sterile filtration,followed by quality control analysis.The average production time of 18F-AV45 preparation was 60 min,the no-corrected efficiency was(32.1±2.1)%(n=5),the radiochemical purity was over 98%,and the appearance color,pH value,in vitro stability,bacterial endotoxin,and residual solvents all met the requirements.18F-AV45 could be synthesized automatically and simply by NEPTIS perform module with good repeatability and the product meets the requirements for clinical use.关键词
Aβ显像剂/18F-AV45/自动化合成/NEPTIS perform模块Key words
Aβ imaging agent/18F-AV45/automated synthesis/NEPTIS perform module分类
核科学引用本文复制引用
王强,唐毅,张月颖,王方洋..基于NEPTIS Perform模块的Aβ显像剂18F-AV45的自动化合成[J].同位素,2025,38(2):141-146,6.
