刘梦捷 1傅毅立 2汪京 2崔松平 2赵晴 2常鑫儿1
作者信息
- 1. 100020 北京,首都医科大学附属北京朝阳医院/北京市呼吸疾病研究所:呼吸与危重症医学科
- 2. 100020 北京,首都医科大学附属北京朝阳医院/北京市呼吸疾病研究所:胸外科
- 折叠
摘要
Abstract
Objective To explore the value of preoperative inflammatory biomarkers in predicting the long-term prognosis of patients with lung adenocarcinoma after Microwave Ablation(MWA).Methods Patients with early-stage lung adenocarcinoma pa-tients who underwent MWA at Beijing Chao-Yang Hospital from January 2012 to June 2021 were included.The area under the curve(AUC)of the receiver's operating characteristic(ROC)curve was used to assess the predictive value of inflammatory biomarkers.Multivariate Cox risk analysis was used to explore the effectiveness of inflammatory biomarkers in predicting outcomes.Results A total of 143 patients were enrolled.The AUC of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune inflammation index(SII),and systemic inflammation response index(SIRI)for overall survival(OS)were 0.787,0.731,0.725,0.780,and 0.802,respectively.The AUC of NLR,PLR,MLR,SII,and SIRI for dis-ease-free survival(DFS)were 0.700,0.623,0.556,0.718,and 0.668,respectively.Cox risk analysis showed that high SII was in-dependently associated with low OS(OR=1.066,P=0.019)and low DFS(OR=1.068,P=0.016).Kaplan-Meier survival analysis revealed that patients with high preoperative SII had significantly worse prognosis(P<0.001).Conclusions Preoperative SII is an ef-fective marker in predicting the long-term prognosis of early-stage lung adenocarcinoma patients after MWA.Other risk factors also in-clude tumor size,degree of differentiation and smoking status.关键词
肺腺癌/微波消融/生物标志物/全身免疫炎症指数/全身炎症反应指数Key words
lung adenocarcinoma/microwave ablation/biomarker/systemic immune inflammation index/systemic inflamma-tion response index分类
临床医学
