摘要
Abstract
Objective To investigate the application value of L3 skeletal muscle index(L3 SMI)in the progression of pancrea-titis.Methods A total of 146 patients with pancreatitis and 143 healthy people from August 2020 to August 2023 at Guangdong Pro-vincial Corps Hospital of Chinese People's Armed Police Force were included in this study.All participants underwent CT examination to determine L3 SMI.Serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-C chemokine ligand 2(CCL2)and leptin were measured by enzyme-linked immunosorbent assay(ELISA),and a four-element linear regression model was established to exclude possible confounding factors.Results After adjusting the model,the L3 SMI index showed a significant decreasing trend in the control group,first-time pancreatitis(FAP)group,recurrent acute pancreatitis(RAP)group,and chronic pancreatitis(CP)group(p-trends of 0.005,0.019,and 0.020,respectively).Leptin was significantly negatively correlated with L3 SMI in all models(Model 1:β=-0.005,P=0.021;Model 2:β=-0.004,P=0.044;Model 3:β=-0.003,P=0.063;Model4:β=-0.004,P=0.054).There was no significant correlation between other factors and L3 SMI.Conclusions L3 SMI decreases gradually during the continuous process from FAP to RAP and CP,and the changes of leptin level may be an important influencing factor.关键词
L3骨骼肌指数/胰腺炎/瘦素Key words
L3 skeletal muscle index/pancreatitis/leptin分类
临床医学
