摘要
Abstract
Objective To explore the predictive value of visual coronary artery calcium score(VCACS)for coronary heart dis-ease(CHD).Methods A retrospective collection of data was conducted on patients who underwent chest CT(with a slice thickness of 1.25 mm)and coronary CT angiography(CCTA)in Southwest Hospital of Army Medical University from July 2018 to July 2023.The imaging data were analyzed by experienced radiologists,and the patients with coronary artery stenosis≥50%on CCTA were included in the CHD group.Agatston scores were derived from the analysis of ECG-gated cardiac CT using specialized software.Spearman's correlation analysis was employed to explore the relationship between Agatston scores and VCACS in all participants,different Agatston score ranges(0-10,11-100,101-400,>400)and age groups(≤65 years,>65 years).Univariate logistic regression analysis was used to assess the association between variables with CHD.After selecting statistically significant variables,multivariate logistic regres-sion was employed to investigate the association between the total VCACS(tVCACS)subgroups and CHD.At the same time,the pre-diction model of XGBoost machine learning algorithm was constructed,and the significance analysis of SHAP features was combined to quantify the predictive value of each feature variable on CHD.Results A total of 287 participants,aged from 30 to 90 years,were in-cluded in the study,with 177 males.A total of 153 participants(53.3%)were classified into the CHD group.In the overall cohort,different Agatston score ranges and age groups,VCACS demonstrated good consistency with Agatston score in assessing the degree of coronary artery calcification.The tVCACS in CHD group was significantly higher than that in non-CHD group.Multivariate logistic re-gression analysis showed that the OR of tVCACS 2-5 group was 2.23(95%CI:1.22-4.08),and the OR of the tVCACS≥6 group was 20.26(95%CI:5.76-71.26),indicating a significantly increased risk of CHD with higher tVCACS.SHAP feature importance analysis also demonstrated that tVCACS had a higher predictive value for CHD risk than other factors.Conclusions VCACS obtained through 1.25 mm chest CT demonstrates a good correlation with Agatston score and has potential clinical application value in predicting CHD.关键词
视觉冠状动脉钙化积分/Agatston积分/计算机断层扫描/冠状动脉计算机断层血管成像Key words
visual coronary artery calcification score/Agatston score/computed tomography/coronary artery computed tomo-graphy angiography分类
医药卫生
