同位素2025，Vol.38Issue(2)：185-190,6.DOI:10.7538/tws.2024.youxian.057
稳定同位素标记3,3',4,4'-四氯联苯-D6的合成及表征
Synthesis and Characterization of Stable Isotope Labeled 3,3',4,4'-Tetrachlorobiphenyl-D6
摘要
Abstract
A new synthetic method of the stable isotope labeled 3,3',4,4'-tetrachlorobiphenyl-D6 was investigated.The synthesis of 3,3',4,4'-tetrachlorobiphenyl-D6 is based on 1,2-dichlorobenzene-D4 as the labeling precursor through three steps of catalyzed borylation,iodination,Suzuki coupling reaction.According to the amount of 1,2-dichlorobenzene-D4,the yield of 3,3',4,4'-tetrachlorobiphenyl-D6 was 72.85%.The structure of the target product was characterized by 1H-NMR,gas-mass spectrometry and gas chromatography.The chemical purity of 3,3',4,4'-tetrachlorobiphenyl-D6 was 99.54%,and the abundance of deuterium isotope was 98.38 atom%D.It can be used as the isotope internal standard for the determination of polychlorinated biphenyls.关键词
多氯联苯/稳定同位素标记/同位素内标Key words
polychlorinated biphenyls/stable isotope labeling/isotope internal standard分类
核科学引用本文复制引用
汪榕,郭会,陈武炼..稳定同位素标记3,3',4,4'-四氯联苯-D6的合成及表征[J].同位素,2025,38(2):185-190,6.基金项目
基础科研条件与重大科学仪器设备研发重点专项(2021YFF0701902) （2021YFF0701902）
上海市2021年度"科技创新行动计划"启明星项目(21QB1400800) （21QB1400800）
