同位素2025，Vol.38Issue(2)：206-216,11.DOI:10.7538/tws.2023.youxian.119
镭-223制备技术研究进展
Research Progress in the Preparation Technology of Radium-223
耿峻山 1吴建荣 1肖茜 1李波 1陈云明 1张劲松 1罗宁1
作者信息
- 1. 中国核动力研究设计院,成都 610213||四川省放射性同位素工程技术研究中心,成都 610213||同位素及药物国家工程研究中心,成都 610213
- 折叠
摘要
Abstract
223Ra is a low toxicity substance α Radiotherapy nuclide,which can be used to treat castrated resistant prostate cancer(CRPC)with symptoms of bone metastasis and no visceral metastasis,was the first approved alpha therapy radiopharmaceutical on the market.In 2013,with the launch of Xofigo(223RaCl2 solution)in the United States,it marked α radionuclide therapy has widely entered people's field of vision.Compared to other commonly used β、γ medical radioactive isotopes,research on 223Ra is still far from sufficient,especially in terms of preparation and separation.In the preparation process of 223Ra,there are difficulties in obtaining raw materials,high dosage,cumbersome separation steps,and many isotopic impurities.In response to these difficulties,various methods for preparing 223Ra have also been studied.This article mainly reviews the preparation methods and separation processes of 223Ra through four methods:separation from natural ores,accelerator preparation,reactor irradiation preparation,and obtaining from actinium/beryllium generators.It also discusses some challenges and prospects in the preparation of 223Ra,providing some reference for efficient separation of 223Ra.关键词
α放射性核素/制备分离/加速器/反应堆/放射性子体Key words
α radioactivity nuclide/separation/accelerator/reactor/radioactive daughter分类
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耿峻山,吴建荣,肖茜,李波,陈云明,张劲松,罗宁..镭-223制备技术研究进展[J].同位素,2025,38(2):206-216,11.
