新医学2025，Vol.56Issue(3)：243-250,8.DOI:10.12464/j.issn.0253-9802.2024-0502
海参多肽的生物活性及其在神经系统疾病中的应用
Research progress on the biological activity of sea cucumber polypeptides and their application in neurological diseases
摘要
Abstract
Sea cucumber polypeptides have garnered significant attention in the treatment of neurological diseases due to their unique structure and diverse biological activities.Recent studies have shown that sea cucumber polypeptides possess biological activities such as antioxidant,anti-inflammatory,and immune modulation,effectively reducing neural inflammation and oxidative stress on nerve cells,thereby protecting neurons.Specifically,the mechanisms by which sea cucumber polypeptides act in neurological diseases,including Alzheimer's disease,Parkinson's disease,and stroke,have become focal points of research in recent years.These polypeptides can positively impact neurodegenerative changes by suppressing inflammatory responses,modulating neurotransmitter levels,and promoting neuroregeneration.Despite promising findings,current studies are mainly focused on in vitro and animal experiments,with relatively limited clinical research evidence;thus,further exploration of their safety and efficacy is required.This paper reviews the primary biological activities of sea cucumber polypeptides and their recent advancements in applications to neurological diseases,providing references for future research and clinical application.关键词
海参多肽/生物活性/神经保护/抗氧化/神经系统疾病Key words
Sea cucumber polypeptides/Biological activity/Neuroprotection/Antioxidant/Neurological diseases引用本文复制引用
龚正,余华军,张海涛..海参多肽的生物活性及其在神经系统疾病中的应用[J].新医学,2025,56(3):243-250,8.基金项目
广东省基础与应用基础研究基金(2024A1515013157) （2024A1515013157）
广东省中医药局科研项目(20231225) （20231225）
