畜牧与兽医2025，Vol.57Issue(4)：130-138,9.
阿司匹林对比格犬消化系统的毒性作用研究
Damaging effects of aspirin on the canine digestive system
摘要
Abstract
To study the damaging effects of aspirin on the canine digestive system,18 healthy dogs were selected,randomly and equally di-vided into three groups which were given 0,10 and 25 mg/kg aspirin in the diet,i.e.the Asp0,Asp10 and Asp25 groups,twice daily for 21 consecutive days.The results showed that,compared with the Asp0 group,the faecal occult blood of the dogs in the Asp25 group became positive from day 1 and got strongly positive intermittently.The endoscopy scores for the dogs were significantly increased from day 4(P＜0.05);and their body weight and coagulation function were significantly decreased in the first week(P＜0.05),as were the serum levels of the immune-related indices interleukin-2(IL-2)and serum lysozyme activity(LZM)(P＜0.05).The content of secretory immunoglobulin A(sIgA)in the intestinal mucosa of the dogs also decreased significantly(P＜0.05).At the end of the experiment,the structure of the gas-tric mucosal layer in them disappeared,their mucosal muscularis propria was damaged,their submucosal layer was edematous,the arrange-ment of the connective tissues was disorganized,and the content of sIgA in their intestinal mucosa was significantly decreased(P＜0.05).In the Asp10 group,there was no significant change in feed intake and body weight during the test.In the third week,the faecal character as-sessment and coagulation function of the group were higher than those of the Asp25 group,and their occult blood score and serum immune-related indexes(IL-2,LZM,and sIgA)were lower than those of the Asp25 group.The pathological histology showed that the gastric epithe-lium of the Asp10 group was damaged,but their muscularis mucosa was structurally intact.The above results indicated that oral administra-tion of 25 mg/kg aspirin to dogs for 21 days caused a decrease in food intake and body weight,gastric mucosal erosion and bleeding,appear-ance of thin and soft bloody stools,a decrease in the body's coagulation function and consequent changes in serum cytokines and mucosal im-mune proteins,which ultimately resulted in damage to the structure and function of the digestive system of the dogs.关键词
阿司匹林/犬/消化系统/损伤作用Key words
aspirin/canine/digestive system/damage effect分类
农业科技引用本文复制引用
刘京,陈勤勤,刘国芳,林家琪,郝盼..阿司匹林对比格犬消化系统的毒性作用研究[J].畜牧与兽医,2025,57(4):130-138,9.基金项目
江苏农林职业技术学院科技项目(2020kj027) （2020kj027）
