畜牧与兽医2025，Vol.57Issue(4)：139-145,7.
产气荚膜梭菌疫苗研究进展
Advances inresearch on Clostridium perfringens vaccine
摘要
Abstract
Clostridium perfringensis a conditionally pathogenic bacterium that is widely present in nature and in the gastrointestinal tract of animals,causing serious economic losses to livestock and poultry breeding.Vaccination is currently the mainstay of prevention and control of C.perfringens and has helped to reduce the use of antimicrobials in livestock farming and to slow down the development of bacterial resist-ance.This paper reviews the application of C.perfringens α,β,and ε toxin proteins as antigenic components of vaccines,and summarizes the research progress in four aspects,namely,toxoid vaccine,bacterial carrier vaccine,nanoparticle vaccine or adjuvant,and multi-epitope vaccine,with a view to providing reference for the development of novel vaccines.关键词
产气荚膜梭菌/疫苗/抗原/毒素蛋白Key words
Clostridium perfringens/vaccine/antigen/toxin protein分类
农业科技引用本文复制引用
曾梦,吴群,韩建成,杨远廷,周汉林..产气荚膜梭菌疫苗研究进展[J].畜牧与兽医,2025,57(4):139-145,7.基金项目
中央级公益性科研院所基本科研业务费专项(1630102024005) （1630102024005）
