新医学2025，Vol.56Issue(3)：316-322,7.DOI:10.12464/j.issn.0253-9802.2024-0293
小胶质细胞极化在神经系统炎症反应中的作用机制
The mechanism of microglial polarization in the inflammatory response of the nervous system
摘要
Abstract
In the central nervous system,microglia account for about 10%of the total number of cells.They are the main immune cells in the nervous system,responsible for immune surveILlance,inflammatory response,and removal of harmful substances.When the nervous system is damaged,infected,or inflammatory,microglia are activated into macrophage-like cells and release inflammatory mediators and cytokines.These molecules can guide the migration of immune cells,regulate inflammatory responses,and participate in the repair and recovery process.In this review,we mainly focus on the activation and mechanism of microglia in the inflammatory response of the nervous system,further explain the inflammatory response process of the nervous system and the role of microglia in some specific neurological diseases.关键词
神经系统炎症反应/小胶质细胞/M1型极化/M2型极化Key words
Inflammatory response in the nervous system/Microglial/M1 polarization/M2 polarization引用本文复制引用
曹文达,胡娜娜,李磊,姚利和,王天红,谷有全..小胶质细胞极化在神经系统炎症反应中的作用机制[J].新医学,2025,56(3):316-322,7.基金项目
甘肃省自然科学基金(22JR5RA941) （22JR5RA941）
