纤维素科学与技术2025，Vol.33Issue(1)：14-20,7.DOI:10.16561/j.cnki.xws.2025.01.11
掺杂ACP的纳米纤维素/壳聚糖纤维复合膜的构建及性能研究
Preparation and Properties of ACP-doped CNF/ChNF Composite Fiber Membrane
摘要
Abstract
Cellulose nanofibers(CNF)and chitosan nanofibers(ChNF)were successfully prepared by TEMPO oxidation method as supporting matrix and achieved induced mineralization of amorphous calcium phosphate(ACP),which promoted the regenerative repair of periodontal tissues.Through the optimized combination of directional freeze-drying and solution casting processes,CNF/ChNF-ACP bilayer composite membranes were prepared with dry and wet fracture strengths of 17.5 MPa and 3.8 MPa,respectively,which significantly enhanced the mechanical properties of the periodontal tissue restoration scaffolds.In vitro cellular and antimicrobial experiments showed that the bilayer membrane could promote the proliferation of MC3T3-E1 cells,and the inhibition rate of E.coli and Staphylococcus aureus was more than 96%,and the CNF/ChNF-ACP bilayer composite membrane showed significant potential for application in the field of oral alveolar bone regeneration,which provided a new material option for periodontal tissue engineering.关键词
纤维素/壳聚糖/纤维膜/TEMPO氧化法/仿生矿化Key words
cellulose/chitosan/fiber membrane/TEMPO oxidation/biomimetic mineralization分类
化学工程引用本文复制引用
李静,邓霁霞,黄晨,冯妍慧芝..掺杂ACP的纳米纤维素/壳聚糖纤维复合膜的构建及性能研究[J].纤维素科学与技术,2025,33(1):14-20,7.基金项目
国家自然基金委青年科学基金项目(82301152) （82301152）
上海市浦江人才计划(D类)(22PJD081). （D类）
