中国防痨杂志2025，Vol.47Issue(4)：513-519,7.DOI:10.19982/j.issn.1000-6621.20240445
钙结合蛋白S100A12与中性粒细胞胞外诱捕网形成在重症肺结核患者肺损伤中作用机制研究进展
Research progresses on the role and mechanism of calcium-binding protein S100A12 and neutrophil extracellular trap formation in lung injury of severe pulmonary tuberculosis patients
摘要
Abstract
The incidence and mortality rates of severe pulmonary tuberculosis remain persistently high.However,the disease face significant diagnostic challenges due to the lack of specificity in clinical signs and symptoms during the early stages of the disease.Furthermore,the therapeutic of severe tuberculosis has become being complicated due to multiple factors,such as drug-drug interactions,drug-disease interactions,and adverse drug reactions,all of which together pose new challenges for tuberculosis prevention and control.The pathogenesis of severe tuberculosis involves a complex interaction between the host and Mycobacterium tuberculosis,yet the mechanism of pathogenesis remains incompletely understood.Recent studies indicate that calcium-binding protein S100A12(hereafter"S100A12")and neutrophil extracellular traps(NETs)are essential in developing severe tuberculosis.S100A12 drives the formation of NETs,and serve as a key protein mediating the physiopathological effects of NETs.S100A12 contributes to the mechanism of lung function injury in severe tuberculosis patients through regulation the release of immune cells,inflammatory cytokine release,and their interaction.Nevertheless,the regulatory mechanisms of S100A12 and NETs in severe tuberculosis pathogenesis has not been fully elucidated.Given this,this review aims to comprehensively summarize the research progress on S100A12 and NETs in severe tuberculosis and their potential molecular mechanisms to provide a new scientific basis and innovative insights for exploring therapeutic strategies for severe tuberculosis.关键词
中性粒细胞/结核,肺/肺损伤/作用机制Key words
Neutrophils/Tuberculosis,pulmonary/Lung injury/Mechanism of action分类
临床医学引用本文复制引用
宋云林,布祖克拉·阿布都艾尼,王桂荣,张继园,鲁晓擘..钙结合蛋白S100A12与中性粒细胞胞外诱捕网形成在重症肺结核患者肺损伤中作用机制研究进展[J].中国防痨杂志,2025,47(4):513-519,7.基金项目
国家自然科学基金(82360381) （82360381）
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2021-JH13) National Natural Science Foundation of China(82360381) （SKL-HIDCA-2021-JH13）
State Key Laboratory of Pathogenesis,Prevention,Treatment of Central Asian High Incidence Diseases Fund of China(SKL-HIDCA-2021-JH13) （SKL-HIDCA-2021-JH13）
